We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis, hydrolysis, and reductive cyclization of ethyl 5-chloro-4-(4-nitropyrrolidin-3-yl)pyrrole-3-carboxylates.
- Authors
Grozav, Alina N.; Kemskiy, Sergiy V.; Fedoriv, Mariana Z.; Chornous, Vitaliy А.; Palamar, Alina А.; Dorokhov, Viktor I.; Rusanov, Eduard B.; Vovk, Mikhailo V.
- Abstract
Ethyl 5-chloro-4-(2-nitroethenyl)pyrrole-3-carboxylates, obtained by the condensation of ethyl 5-chloro-4-formylpyrrole-3-carboxylates with nitromethane, react with N-methylazomethine ylide with the formation of ethyl 5-chloro-4-(4-nitropyrrolidin-3-yl)pyrrole-3-carboxylates. Their hydrolysis yielded the corresponding acids, while reductive cyclization led to the synthesis of hexahydrodipyrrolo[3,4-b:3',4'-d]pyridin-5(1Н)-one via intermediate ethyl 4-(4-aminopyrrolidin-3-yl)-5-chloropyrrole-3-carboxylate derivatives.
- Subjects
HYDROLYSIS; RING formation (Chemistry); NITROMETHANE; CONDENSATION; ACIDS
- Publication
Chemistry of Heterocyclic Compounds, 2022, Vol 58, Issue 1, p24
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-022-03052-3