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- Title
Synthesis of 4-Azapodophyllotoxins with Anticancer Activity by Multicomponent Reactions (Review).
- Authors
Botes, M.; Pelly, S.; Blackie, M.; Kornienko, A.; Otterlo, W.
- Abstract
In the last 13 years, considerable advances have been made in the development of 4-azapodophyllotoxins as anticancer agents. The current review covers this research with an emphasis on the synthesis of less stereochemically complex podophyllotoxin analogs by efficient multicomponent reactions. After a short introduction to the 4-azapodophyllotoxins prepared by such reactions, the debate concerning their exact mechanisms is highlighted. This is followed by a description of 4-azapodophyllotoxin libraries and a discussion of their documented anticancer activities. The review concludes with an analysis of the proposed mode of action and possible future directions in this fascinating area of research.
- Subjects
ANTINEOPLASTIC agent development; PODOPHYLLOTOXIN; STEREOCHEMISTRY; CANCER chemotherapy; PODOPHYLLUM peltatum
- Publication
Chemistry of Heterocyclic Compounds, 2014, Vol 50, Issue 2, p119
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-014-1455-x