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- Title
Graphene oxide‐l‐arginine nanogel: A pH‐sensitive fluorouracil nanocarrier.
- Authors
Malekimusavi, Hanieh; Ghaemi, AmirHossein; Masoudi, Ghasem; Chogan, Faraz; Rashedi, Hamid; Yazdian, Fatemeh; Omidi, Meisam; Javadi, Shohreh; Haghiralsadat, Bibi Fatemeh; Teimouri, Masoumeh; Faal Hamedani, Naghmeh
- Abstract
Nowadays, putting forward an accurate cancer therapy method with minimal side effects is an important topic of research. Nanostructures, for their ability in controlled and targeted drug release on specific cells, are critical materials in this field. In this study, a pH‐sensitive graphene oxide‐l‐arginine nanogel was synthesized to carry and release 5‐fluorouracil. Optimized conditions using statistical analysis, based on the maximum relative viscosity of nanogel, were evaluated: 5.489 for the concentration of l‐arginine and 2.404 for pH. The prepared nanogels were characterized using scanning electron microscope and transmission electron microscope images and Fourier‐transform infrared spectroscopic analysis. Cytotoxicity was assessed using the sulforhodamine B (SRB) assay on MCF‐7 breast cancer cells. The fluorouracil release was measured by the dialysis bag method, UV spectrophotometry, and fluorouracil calibration diagram. Results proved the successful controlled release of fluorouracil at pH 5.4 and the beneficial role of graphene‐oxide‐ l‐arginine‐ fluorouracil nanogel in eliminating cancer cells.
- Subjects
CONTROLLED release drugs; SCANNING electron microscopes; GRAPHENE; DRUG side effects; CANCER cells; TRANSMISSION electron microscopes
- Publication
Biotechnology & Applied Biochemistry, 2019, Vol 66, Issue 5, p772
- ISSN
0885-4513
- Publication type
Article
- DOI
10.1002/bab.1768