We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Amino Acids May Have Protective Effects on Salivary Glands of 5-FU-administered Mice.
- Authors
RIEKO FUJIWARA; KOJI HARADA; TARANNUM FERDOUS; KATSUAKI MISHIMA
- Abstract
Background/Aim: This study aimed to identify the most useful components of Elental® in the treatment of 5- fluorouracil (FU)-induced mucositis and salivary gland atrophy in mice. Materials and Methods: Mice (except the control group) were intraperitoneally injected with 5-FU. The mice received saline (control group and 5-FU group), dextrin (Dextrin group), amino acids (17AA group), or Elental® (Elental® group). Results: The volume and weight of salivary glands was higher in 17AA and Elental® groups compared to 5-FU group. The number of mucous glands was higher, whereas the number of damaged granular ductal epithelial cells was lower in the salivary glands of all groups except the 5-FU group. Salivation was also decreased in the 5-FU group compared to the other groups. Conclusion: Amino acids could be the most effective components of Elental® for protecting mouse salivary glands from 5-FUinduced atrophic changes, and might be useful in the treatment of oral mucositis in cancer patients.
- Subjects
AMINO acids; FLUOROURACIL; DEXTRINS; SALIVARY glands; CANCER patients
- Publication
In Vivo, 2022, Vol 36, Issue 1, p198
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.12691