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- Title
Conventional imaging and 2-deoxy-2-[<sup>18</sup>F]fluoro-D-glucose positron emission tomography for predicting the clinical outcome of patients with previously treated Hodgkin's disease
- Authors
Filmont, Jean-Emmanuel; Yap, Cecelia S.; Ko, Fred; Vranjesevic, Duska; Quon, Andrew; Margolis, Daniel J.A.; Safaei, Arash; Emmanouilides, Christos; Silverman, Daniel H.S.; Phelps, Michael E.; Czernin, Johannes
- Abstract
: PurposeThe aim of this study was to determine the ability of 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography (FDG-PET) to predict the clinical outcome of previously treated patients with Hodgkin''s Disease (HD).: Patients and methodsThirty-two patients were studied with PET within a median interval of 5.2 months after treatment. Conventional imaging (CI) performed within two months before PET included 2.9±1.2 imaging tests/patient. To determine the independent ability of FDG-PET to predict the clinical outcome, PET images were reread without knowledge of CI and clinical history. Study end points were disease-free survival, or clinical evidence of disease or death. PET and CI stages were also compared for each patient.: ResultsUsing the clinical outcome as gold standard after a median follow-up of 14 months, 21 of 32 patients (65%) were considered disease-free while 11 of 32 patients (35%) had evidence for disease or had died. The predictive accuracy of PET was 91% vs. 66% for conventional imaging (P<0.05). The positive predictive value (PPV) was also significantly higher for PET (79% vs. 50%, P<0.05), while its negative predictive value (NPV) tended to be higher than that of CI (100% vs. 86%, P = 0.08). Kaplan-Meier analysis for disease-free survival showed a significant difference between PET-negative and -positive results. No such difference was observed between CI-positive and -negative results (P = 0.35).: ConclusionWhole-body FDG-PET imaging modified the clinical stage in 28% of patients. Moreover, FDG-PET predicted patient outcome with a higher predictive accuracy than CI. This superior prognostic accuracy was achieved with a single FDG-PET study vs. 2.9±1.2 CI procedures/patient.
- Subjects
POSITRON emission tomography; POSITRON emission; COMPUTER-aided diagnosis; DIAGNOSTIC imaging; HODGKIN'S disease
- Publication
Molecular Imaging & Biology, 2004, Vol 6, Issue 1, p47
- ISSN
1536-1632
- Publication type
journal article
- DOI
10.1016/S1536-1632(03)00107-0