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- Title
Utilizing ion mobility and tandem mass spectrometry to evaluate the structure and behaviour of multimeric cyclodextrin complexes.
- Authors
Berland, Kevin; Renaud, Justin B.; Mayer, Paul M.
- Abstract
Characterizing noncovalent complexes of molecular dimers and higher complexes using tandem mass spectrometry (MS/MS) can be hindered due to spectral overlap in both the MS and the MS/MS. We investigated the structures and dissociation energetics of multimeric β-cyclodextrin (β-CD) complexes alone or with substrates using combinations of ion mobility spectrometry (IMS), MS/MS, and Rice-Ramsperger-Kassel-Marcus (RRKM) unimolecular rate modelling. The doubly charged β-CD dimers ([(β-CD)2 - 2H+]2−) dissociate to two [β-CD - H+]− ions with the same m/ z. IMS was used to separate source generated [(β-CD)2 - 2H+]2− from [β-CD - H+]− and the extent of [(β-CD)2 - 2H+]2− dissociation versus collision energy was determined by modelling changes in the ion's isotopic profile. The RRKM derived critical energy ( E0) for dissociation of [(β-CD)2 - H+]− and [(β-CD)2 - 2H+]2− were 1.85 ± 0.11 eV and 1.79 ± 0.09 eV, respectively, corresponding to a slight decrease in complex stability due to increased charge-charge repulsion in the dianion. This approach was extended to include dimeric complexes complexed to 4,4′-(propane-1,3-diyl) dibenzoic acid (PDDA) and ibuprofen (Ibu).
- Subjects
CYCLODEXTRINS; ION mobility; CHARGE carrier mobility; TANDEM mass spectrometry; MASS spectrometry
- Publication
Canadian Journal of Chemistry, 2015, Vol 93, Issue 12, p1313
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/cjc-2014-0419