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- Title
Radioactive Iodine Treatment and the Risk of Long-Term Cardiovascular Morbidity and Mortality in Thyroid Cancer Patients: A Nationwide Cohort Study.
- Authors
Kao, Chun-Hao; Chung, Chi-Hsiang; Chien, Wu-Chien; Shen, Daniel Hueng-Yuan; Lin, Li-Fan; Chiu, Chuang-Hsin; Cheng, Cheng-Yi; Sun, Chien-An; Chang, Ping-Ying
- Abstract
(1) Background: This study aimed to investigate the association between radioactive iodine (RAI) and long-term cardiovascular disease (CVD) morbidity/mortality in thyroid cancer. (2) Methods: The study was conducted using data from the Taiwan National Health Insurance Database during 2000–2015. Thyroid cancer patients aged ≥20 years were categorized into RAI (thyroidectomy with RAI) and non-RAI (thyroidectomy only) groups. The Cox proportional hazard regression model and Kaplan–Meier method were used for analysis. (3) Results: A total of 13,310 patients were included. Kaplan–Meier analysis demonstrated that the two groups had similar cumulative risks of CVD (log-rank p = 0.72) and CVD-specific mortality (log-rank p = 0.62). On Cox regression analysis of different RAI doses, the risk of CVD was higher in the cumulative dosage >3.7 GBq (hazard ratio = 1.69, 95% confidence interval = 1.24–2.40, p < 0.001). (4) Conclusions: RAI was not associated with an increased risk of CVD in thyroid cancer. However, CVD surveillance is indicated in the patients receiving the cumulative RAI dosage above 3.7 GBq.
- Subjects
CANCER-related mortality; IODINE isotopes; THYROID cancer; CARDIOVASCULAR diseases risk factors; PROPORTIONAL hazards models; COHORT analysis
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 17, p4032
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10174032