We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Switch of cadherin expression as a diagnostic tool for Leydig cell tumours.
- Authors
Bremmer, F; Schweyer, S; Martin‐Ortega, M; Hemmerlein, B; Strauss, A; Radzun, HJ; Behnes, CL
- Abstract
Leydig cell tumours comprise about 3% of all testicular tumours. The pathogenesis of Leydig cell tumours is still poorly understood. We investigated testis with Leydig cell hyperplasia and Leydig cell tumours for their expression pattern of P- and N-cadherin. We could show a switch of expression of P- and N-cadherin in Leydig cell hyperplasia and Leydig cell tumours in comparison with normal Leydig cells. Cadherins could be established as a new immunohistochemical marker for this testicular tumour entity; their possible role in tumour genesis will be discussed.
- Subjects
LEYDIG cell tumors; TESTIS tumors; TESTICULAR cancer; CADHERINS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY
- Publication
APMIS, 2013, Vol 121, Issue 10, p976
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1111/apm.12053