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- Title
Fungal Allergy: from Asthma to Alveolitis.
- Authors
Fink, Jordan N.
- Abstract
Sensitization and recurrent exposure to fungi may result in a variety of respiratory syndromes related to the allergic response of the host. Responses which are largely lgE in nature result in the typical allergic diseases of asthma and rhinitis. Fungal colonization of the sinuses may induce a disorder characterized by mucinous and eosinophilic secretions and elevated serum lgE levels known as allergic fungal sinusitis. Colonization of the airway by fungi may induce the inflammatory response of allergic bronchopulmonary mycosis, with immunologic features similar to allergic fungal sinusitis, but with characteristic proximal bronchiectasis. Repeated inhalational exposure to fungi may also induce an allergic alveolitis characterized by delayed respiratory and systemic symptoms, a lymphocytic alveotitis and progression to fibrosis with repeated exposure. Immune mechanisms other than those related to lgE appear to be involved in this disease.
- Subjects
ASTHMA; ALVEOLITIS; RHINITIS; IMMUNOLOGY
- Publication
Indoor Air, 1998, Vol 8, p50
- ISSN
0905-6947
- Publication type
Article
- DOI
10.1111/j.1600-0668.1998.tb00008.x