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- Title
Evaluating Patient Brain and Behavior Pathways to Caregiver Health in Neurodegenerative Diseases.
- Authors
Hua, Alice Y.; Wells, Jenna L.; Haase, Claudia M.; Chen, Kuan-Hua; Rosen, Howard J.; Miller, Bruce L.; Levenson, Robert W.
- Abstract
Background: Caregivers of patients with neurodegenerative diseases are at heightened risk for serious health problems, but health differences between individual caregivers abound. Aims: To determine whether atrophy in patient brains could be used to identify caregivers at heightened risk for health problems and which patient variables mediate this relationship. Methods: In 162 patient-caregiver dyads, we assessed patient atrophy using structural MRI, caregiver health, and patient behavior and cognitive symptoms. Results: Patient atrophy in the right insula and medial frontal gyrus was associated with worse caregiver health; this relationship was partially mediated by patient neuropsychiatric symptoms, and assessing atrophy in these regions improved predictions of poor caregiver health above and beyond patient behavioral symptoms. Conclusions: This study shows the value of patients' brain data in identifying caregivers at risk for becoming sick themselves.
- Subjects
CAREGIVERS; CEREBRAL cortex; COGNITION disorders; FRONTAL lobe; HEALTH status indicators; INTERPERSONAL relations; MAGNETIC resonance imaging; NEURODEGENERATION; RISK assessment; ATROPHY; PATIENTS' attitudes
- Publication
Dementia & Geriatric Cognitive Disorders, 2019, Vol 47, Issue 1/2, p42
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000495345