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- Title
Perinatal Depressive Symptoms and Viral Non-suppression Among a Prospective Cohort of Pregnant Women Living with HIV in Nigeria, Kenya, Uganda, and Tanzania.
- Authors
Concepcion, Tessa; Velloza, Jennifer; Kemp, Christopher G.; Bhat, Amritha; Bennett, Ian M.; Rao, Deepa; Polyak, Christina S.; Ake, Julie A.; Esber, Allahna; Dear, Nicole; Maswai, Jonah; Owuoth, John; Sing'oei, Valentine; Bahemana, Emmanuel; Iroezindu, Michael; Kibuuka, Hannah; Collins, Pamela Y.
- Abstract
Depression is common during pregnancy and is associated with reduced adherence to HIV-related care, though little is known about perinatal trajectories of depression and viral suppression among women living with HIV (WLHV) in sub-Saharan Africa. We sought to assess any association between perinatal depressive symptoms and viral non-suppression among WLWH. Depressive symptomatology and viral load data were collected every 6 months from WLWH enrolled in the African Cohort Study (AFRICOS; January 2013–February 2020). Generalized estimating equations modeled associations between depressive symptoms [Center for Epidemiological Studies Depression (CES-D) ≥ 16] and viral non-suppression. Of 1722 WLWH, 248 (14.4%) had at least one pregnancy (291 total) and for 61 pregnancies (21.0%), women reported depressive symptoms (13.4% pre-conception, 7.6% pregnancy, 5.5% one-year postpartum). Depressive symptomatology was associated with increased odds of viral non-suppression (aOR 2.2; 95% CI 1.2–4.0, p = 0.011). Identification and treatment of depression among women with HIV may improve HIV outcomes for mothers.
- Subjects
TANZANIA; KENYA; NIGERIA; UGANDA; HIV-positive persons; STATISTICAL power analysis; HIV infections; PREMATURE infants; CONFIDENCE intervals; POSTPARTUM depression; VIRAL load; MISCARRIAGE; SELF-evaluation; MULTIVARIATE analysis; PREGNANT women; ACQUISITION of data; ANTIRETROVIRAL agents; PREGNANCY outcomes; RISK assessment; PSYCHOLOGICAL tests; MENTAL depression; PREGNANCY complications; CENTER for Epidemiologic Studies Depression Scale; MEDICAL records; DESCRIPTIVE statistics; DRUGS; RESEARCH funding; ODDS ratio; STATISTICAL models; PATIENT compliance; DATA analysis software; SOCIODEMOGRAPHIC factors; PERINATAL period; VERTICAL transmission (Communicable diseases); LONGITUDINAL method; HIV; DISEASE risk factors
- Publication
AIDS & Behavior, 2023, Vol 27, Issue 3, p783
- ISSN
1090-7165
- Publication type
Article
- DOI
10.1007/s10461-022-03810-6