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- Title
Clinical Effects of the Neutrophil-to-Lymphocyte Ratio/Serum Albumin Ratio in Patients with Gastric Cancer after Gastrectomy.
- Authors
Onuma, Shizune; Hashimoto, Itaru; Suematsu, Hideaki; Nagasawa, Shinsuke; Kanematsu, Kyohei; Aoyama, Toru; Yamada, Takanobu; Rino, Yasushi; Ogata, Takashi; Oshima, Takashi
- Abstract
Preoperative inflammatory and nutritional statuses have potential prognostic effects on patients with gastric cancer (GC) after curative gastrectomy. We investigated the prognostic usefulness of the preoperative neutrophil-to-lymphocyte ratio/albumin ratio (NLR/Alb) in patients with GC. Among 483 patients who underwent gastrectomy for GC, the preoperative prognostic nutritional index (PNI), NLR, and NLR/Alb were calculated using preoperative blood test data. The patients were divided into the high and low PNI, NLR, and NLR/Alb groups. The associations of preoperative PNI, NLR, and NLR/Alb with clinicopathological features, 3-year (3Y) overall survival (OS) rates, and relapse-free survival (RFS) rates after gastrectomy for GC were evaluated. The number of female individuals and the C-reactive protein levels were significantly higher in the high- compared to the low-NLR/Alb group (both p < 0.05). The 3Y OS and 3Y RFS rates following gastrectomy were significantly lower in the high- compared to the low-NLR/Alb group (88.2% vs. 97.8%, p = 0.003 and 84.2% vs. 95.6%, p = 0.002, respectively). In multivariate analysis, high NLR/Alb could independently predict prognosis and recurrence (hazard ratio [HR]: 4.13; 95% confidence interval [CI]: 1.26–13.55; p = 0.02 and HR: 3.16; 95% CI: 1.34–7.45, p = 0.009, respectively). Preoperative NLR/Alb might be a useful prognostic factor for patients with GC after curative gastrectomy.
- Subjects
NEUTROPHIL lymphocyte ratio; STOMACH cancer; GASTRECTOMY; CANCER patients; C-reactive protein
- Publication
Journal of Personalized Medicine, 2023, Vol 13, Issue 3, p432
- ISSN
2075-4426
- Publication type
Article
- DOI
10.3390/jpm13030432