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- Title
Long-Term Tacrolimus Blood Trough Level and Patient Survival in Adult Liver Transplantation.
- Authors
Hsiao, Chih-Yang; Ho, Ming-Chih; Ho, Cheng-Maw; Wu, Yao-Ming; Lee, Po-Huang; Hu, Rey-Heng; Bell, Aaron W.
- Abstract
Tacrolimus is the most widely used immunosuppressant in liver transplant (LT) patients. However, the ideal long-term target level for these patients is unknown. This retrospective study aimed to investigate the impact of tacrolimus blood concentration five years after LT on long-term patient survival outcomes in adult LT recipients. Patients who underwent LT between January 2004 and July 2014 at a tertiary medical center were included in this study (n = 189). The mean tacrolimus blood concentrations of each patient during the fifth year after LT were recorded and the overall survival rate was determined. A multivariate analysis of factors associated with long-term survival was conducted using a Cox's model. The median follow-up period was 9.63 years, and 144 patients (76.2%) underwent live donor LT. Sixteen patients died within 5 years of LT. In the Cox's model, patients with a mean tacrolimus blood trough level of 4.6–10.2 ng/mL had significantly better long-term survival than those with a mean tacrolimus blood trough level outside this range (estimated hazard ratio = 4.76; 95% confidence interval: 1.34–16.9, p = 0.016). Therefore, a tacrolimus level no lower than 4.6 ng/mL would be recommended in adult LT patients.
- Subjects
LIVER transplantation; TACROLIMUS; ADULTS; FACTOR analysis; MULTIVARIATE analysis
- Publication
Journal of Personalized Medicine, 2021, Vol 11, Issue 2, p90
- ISSN
2075-4426
- Publication type
Article
- DOI
10.3390/jpm11020090