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- Title
TFA Mediated Ring-Opening for Evodiamine to Prepare Novel Tryptamine Derivatives.
- Authors
Wei, Hongzhuo; Wang, XH; Guo, Weihang; Wang, Y. H; Zhao, C. K.
- Abstract
Summary: A convenient feasible protocol was developed for the preparation of novel tryptamine derivatives from evodiamine. After the general alkylation in N-13 and followed by the treatment of TFA in chloroform, a series of tryptamine derivatives 4a-i were successfully synthesized in a good yield, which were immediately cyclized to form alcohol 5 in the condition of NaOH/methanol.
- Subjects
TRYPTAMINE; ALKYLATION; CHLOROFORM; METHANOL
- Publication
Journal of the Chemical Society of Pakistan, 2024, Vol 46, Issue 1, p70
- ISSN
0253-5106
- Publication type
Article
- DOI
10.52568/001429/jcsp/46.01.2024