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- Title
Role of vascular calcification inhibitors in preventing vascular dysfunction and mortality in hemodialysis patients.
- Authors
Gungor, Ozkan; Kocyigit, Ismail; Yilmaz, Mahmut Ilker; Sezer, Siren
- Abstract
Cardiovascular events make up the primary cause of death in hemodialysis patients, and the risk for cardiovascular mortality is significantly increased by vascular calcification, a condition observed frequently in this patient population. The mechanisms underlying the pathogenesis of vascular calcification are complex, and many factors facilitate or hinder the development of calcification. In this review, we first summarize the main factors contributing to the pathogenesis of vascular calcification in patients with end-stage renal disease. We then explore the role of calcification inhibitors in the calcification process, as well as their effect on vascular dysfunction and mortality in hemodialysis patients.
- Subjects
TREATMENT of vascular diseases; HEMODIALYSIS patients; CARDIOVASCULAR disease related mortality; CALCIFICATION; CHRONIC kidney failure; PREVENTION; PATIENTS; CARDIOVASCULAR disease prevention; TREATMENT of chronic kidney failure; THERAPEUTIC use of proteins; GLYCOPROTEINS; CELL receptors; CARDIOTONIC agents; CARDIOVASCULAR diseases; CAUSES of death; HEMODIALYSIS; LONGITUDINAL method; RISK assessment; SURVIVAL analysis (Biometry); TREATMENT effectiveness; CALCINOSIS; DIAGNOSIS; THERAPEUTICS
- Publication
Seminars in Dialysis, 2018, Vol 31, Issue 1, p72
- ISSN
0894-0959
- Publication type
journal article
- DOI
10.1111/sdi.12616