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Identification of 3,4-Dihydro-2 H ,6 H -pyrimido[1,2- c ][1,3]benzothiazin-6-imine Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 13, p. 7236, doi. 10.3390/ijms22137236
By:
- Hartuti, Endah Dwi;
- Sakura, Takaya;
- Tagod, Mohammed S. O.;
- Yoshida, Eri;
- Wang, Xinying;
- Mochizuki, Kota;
- Acharjee, Rajib;
- Matsuo, Yuichi;
- Tokumasu, Fuyuki;
- Mori, Mihoko;
- Waluyo, Danang;
- Shiomi, Kazuro;
- Nozaki, Tomoyoshi;
- Hamano, Shinjiro;
- Shiba, Tomoo;
- Kita, Kiyoshi;
- Inaoka, Daniel Ken
Publication type:
Article
Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria.
Published in:
International Journal of Molecular Sciences, 2015, v. 16, n. 7, p. 15287, doi. 10.3390/ijms160715287
By:
- Daniel Ken Inaoka;
- Tomoo Shiba;
- Dan Sato;
- Balogun, Emmanuel Oluwadare;
- Tsuyoshi Sasaki;
- Madoka Nagahama;
- Masatsugu Oda;
- Shigeru Matsuoka;
- Junko Ohmori;
- Teruki Honma;
- Masayuki Inoue;
- Kiyoshi Kita;
- Shigeharu Harada
Publication type:
Article
The hyperthermophilic cystathionine γ-synthase from the aerobic crenarchaeon Sulfolobus tokodaii: expression, purification, crystallization and structural insights.
Published in:
Acta Crystallographica: Section F, Structural Biology Communications, 2017, v. 73, n. 3, p. 152, doi. 10.1107/S2053230X17002011
By:
- Sato, Dan;
- Shiba, Tomoo;
- Mizuno, Sae;
- Kawamura, Ayaka;
- Hanada, Shoko;
- Yamada, Tetsuya;
- Shinozaki, Mai;
- Yanagitani, Masahiko;
- Tamura, Takashi;
- Inagaki, Kenji;
- Harada, Shigeharu
Publication type:
Article
Functional importance of Crenarchaea-specific extra-loop revealed by an X-ray structure of a heterotetrameric crenarchaeal splicing endonuclease.
Published in:
Nucleic Acids Research, 2009, v. 37, n. 14, p. 4787, doi. 10.1093/nar/gkp506
By:
- Yoshinari, Shigeo;
- Shiba, Tomoo;
- Inaoka, Daniel-Ken;
- Itoh, Takashi;
- Kurisu, Genji;
- Harada, Shigeharu;
- Kita, Kiyoshi;
- Watanabe, Yoh-ichi
Publication type:
Article
Pharmacophore Modeling for Anti-Chagas Drug Design Using the Fragment Molecular Orbital Method.
Published in:
PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0125829
By:
- Yoshino, Ryunosuke;
- Yasuo, Nobuaki;
- Inaoka, Daniel Ken;
- Hagiwara, Yohsuke;
- Ohno, Kazuki;
- Orita, Masaya;
- Inoue, Masayuki;
- Shiba, Tomoo;
- Harada, Shigeharu;
- Honma, Teruki;
- Balogun, Emmanuel Oluwadare;
- da Rocha, Josmar Rodrigues;
- Montanari, Carlos Alberto;
- Kita, Kiyoshi;
- Sekijima, Masakazu
Publication type:
Article
Crystal structure of GlcAT-S, a human glucuronyltransferase, involved in the biosynthesis of the HNK-1 carbohydrate epitope.
Published in:
Proteins, 2006, v. 65, n. 2, p. 499, doi. 10.1002/prot.21118
By:
- Shiba, Tomoo;
- Kakuda, Shinako;
- Ishiguro, Masaji;
- Morita, Ippei;
- Oka, Shogo;
- Kawasaki, Toshisuke;
- Wakatsuki, Soichi;
- Kato, Ryuichi
Publication type:
Article
Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics.
Published in:
Frontiers in Microbiology, 2023, p. 1, doi. 10.3389/fmicb.2023.1276447
By:
- Touya Toyomoto;
- Katsuhiko Ono;
- Tomoo Shiba;
- Kenta Momitani;
- Tianli Zhang;
- Hiroyasu Tsutsuki;
- Takeshi Ishikawa;
- Kanae Hoso;
- Koma Hamada;
- Azizur Rahman;
- Liping Wen;
- Yosuke Maeda;
- Keiichi Yamamoto;
- Masao Matsuoka;
- Kenjiro Hanaoka;
- Takuro Niidome;
- Takaaki Akaike;
- Tomohiro Sawa
Publication type:
Article
Molecular mechanism of ubiquitin recognition by GGA3 GAT domain.
Published in:
Genes to Cells, 2005, v. 10, n. 7, p. 639, doi. 10.1111/j.1365-2443.2005.00865.x
By:
- Kawasaki, Masato;
- Shiba, Tomoo;
- Shiba, Yoko;
- Yamaguchi, Yoshiki;
- Matsugaki, Naohiro;
- Igarashi, Noriyuki;
- Suzuki, Mamoru;
- Kato, Ryuichi;
- Kato, Koichi;
- Nakayama, Kazuhisa;
- Wakatsuki, Soichi
Publication type:
Article
Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase.
Published in:
Molecular Microbiology, 2014, v. 94, n. 6, p. 1315, doi. 10.1111/mmi.12831
By:
- Balogun, Emmanuel Oluwadare;
- Inaoka, Daniel Ken;
- Shiba, Tomoo;
- Kido, Yasutoshi;
- Tsuge, Chiaki;
- Nara, Takeshi;
- Aoki, Takashi;
- Honma, Teruki;
- Tanaka, Akiko;
- Inoue, Masayuki;
- Matsuoka, Shigeru;
- Michels, Paul A. M.;
- Kita, Kiyoshi;
- Harada, Shigeharu
Publication type:
Article
X-ray crystal structure of the light-independent protochlorophyllide reductase.
Published in:
Nature, 2010, v. 465, n. 7294, p. 110, doi. 10.1038/nature08950
By:
- Muraki, Norifumi;
- Nomata, Jiro;
- Ebata, Kozue;
- Mizoguchi, Tadashi;
- Shiba, Tomoo;
- Tamiaki, Hitoshi;
- Kurisu, Genji;
- Fujita, Yuichi
Publication type:
Article
Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei.
Published in:
FASEB Journal, 2019, v. 33, n. 11, p. 13002, doi. 10.1096/fj.201901342R
By:
- Balogun, Emmanuel Oluwadare;
- Inaoka, Daniel Ken;
- Tomoo Shiba;
- Chiaki Tsuge;
- May, Benjamin;
- Tomohiro Sato;
- Yasutoshi Kido;
- Takeshi Nara;
- Takashi Aoki;
- Teruki Honma;
- Akiko Tanaka;
- Masayuki Inoue;
- Shigeru Matsuoka;
- Michels, Paul A. M.;
- Yoh-Ichi Watanabe;
- Moore, Anthony L.;
- Shigeharu Harada;
- Kiyoshi Kita
Publication type:
Article
Molecular Basis for Autoregulatory Interaction Between GAE Domain and Hinge Region of GGA1.
Published in:
Traffic, 2007, v. 8, n. 7, p. 904, doi. 10.1111/j.1600-0854.2007.00577.x
By:
- Inoue, Michio;
- Shiba, Tomoo;
- Ihara, Kentaro;
- Yamada, Yusuke;
- Hirano, Satoshi;
- Kamikubo, Hironari;
- Kataoka, Mikio;
- Kawasaki, Masato;
- Kato, Ryuichi;
- Nakayama, Kazuhisa;
- Wakatsuki, Soichi
Publication type:
Article
Insights into the Phosphoregulation of β-Secretase Sorting Signal by the VHS Domain of GGA1.
Published in:
Traffic, 2004, v. 5, n. 6, p. 437, doi. 10.1111/j.1600-0854.2004.00188.x
By:
- Shiba, Tomoo;
- Kametaka, Satoshi;
- Kawasaki, Masato;
- Shibata, Masahiro;
- Waguri, Satoshi;
- Uchiyama, Yasuo;
- Wakatsuki, Soichi
Publication type:
Article
Biochemical characterization of highly active Trypanosoma brucei gambiense glycerol kinase, a promising drug target.
Published in:
Journal of Biochemistry, 2013, v. 154, n. 1, p. 77, doi. 10.1093/jb/mvt037
By:
- Balogun, Emmanuel Oluwadare;
- Inaoka, Daniel Ken;
- Shiba, Tomoo;
- Kido, Yasutoshi;
- Nara, Takeshi;
- Aoki, Takashi;
- Honma, Teruki;
- Tanaka, Akiko;
- Inoue, Masayuki;
- Matsuoka, Shigeru;
- Michels, Paul AM.;
- Harada, Shigeharu;
- Kita, Kiyoshi
Publication type:
Article
Crystal structure of mitochondrial quinol–fumarate reductase from the parasitic nematode Ascaris suum.
Published in:
Journal of Biochemistry, 2012, v. 151, n. 6, p. 589, doi. 10.1093/jb/mvs051
By:
- Shimizu, Hironari;
- Osanai, Arihiro;
- Sakamoto, Kimitoshi;
- Inaoka, Daniel Ken;
- Shiba, Tomoo;
- Harada, Shigeharu;
- Kita, Kiyoshi
Publication type:
Article
The Role of Amino Acid Residues in the Active Site of L-Methionine ɣ-lyase from Pseudomonas putida.
Published in:
Bioscience, Biotechnology & Biochemistry, 2012, v. 76, n. 7, p. 1275, doi. 10.1271/bbb.110906
By:
- FUKUMOTO, Mitsuki;
- KUDOU, Daizou;
- MURANO, Shouko;
- SHIBA, Tomoo;
- SATO, Dan;
- TAMURA, Takashi;
- HARADA, Shigeharu;
- INAGAKI, Kenji
Publication type:
Article
Structural basis for recognition of acidic-cluster dileucine sequence by GGA1.
Published in:
Nature, 2002, v. 415, n. 6874, p. 937, doi. 10.1038/415937a
By:
- Shiba, Tomoo;
- Takatsu, Hiroyuki;
- Nogi, Terukazu;
- Matsugaki, Naohiro;
- Kawasaki, Masato;
- Igarashi, Noriyuki;
- Suzuki, Mamoru;
- Kato, Ryuichi;
- Earnest, Thomas;
- Nakayamas, Kazuhisa;
- Wakatsuki, Soichi
Publication type:
Article
Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Published in:
Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00997
By:
- Yukiko Miyazaki;
- Inaoka, Daniel K.;
- Tomoo Shiba;
- Hiroyuki Saimoto;
- Takaya Sakura;
- Eri Amalia;
- Yasutoshi Kido;
- Chika Sakai;
- Mari Nakamura;
- Moore, Anthony L.;
- Shigeharu Harada;
- Kiyoshi Kita
Publication type:
Article
The Open Form Inducer Approach for Structure-Based Drug Design.
Published in:
PLoS ONE, 2016, v. 11, n. 11, p. 1, doi. 10.1371/journal.pone.0167078
By:
- Inaoka, Daniel Ken;
- Iida, Maiko;
- Tabuchi, Toshiyuki;
- Honma, Teruki;
- Lee, Nayoung;
- Hashimoto, Satoshi;
- Matsuoka, Shigeru;
- Kuranaga, Takefumi;
- Sato, Kazuhito;
- Shiba, Tomoo;
- Sakamoto, Kimitoshi;
- Balogun, Emmanuel Oluwadare;
- Suzuki, Shigeo;
- Nara, Takeshi;
- Rocha, Josmar Rodrigues da;
- Montanari, Carlos Alberto;
- Tanaka, Akiko;
- Inoue, Masayuki;
- Kita, Kiyoshi;
- Harada, Shigeharu
Publication type:
Article
The alternative oxidases: simple oxidoreductase proteins with complex functions.
Published in:
Biochemical Society Transactions, 2013, v. 41, n. 5, p. 1305, doi. 10.1042/BST20130073
By:
- Young, Luke;
- Tomoo Shiba;
- Shigeharu Harada;
- Kiyoshi Kita;
- Albury, Mary S.;
- Moore, Anthony L.
Publication type:
Article
Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport.
Published in:
Nature Structural Biology, 2003, v. 10, n. 5, p. 386, doi. 10.1038/nsb920
By:
- Shiba, Tomoo;
- Kawasaki, Masato;
- Takatsu, Hiroyuki;
- Nogi, Terukazu;
- Matsugaki, Naohiro;
- Igarashi, Noriyuki;
- Suzuki, Mamoru;
- Kato, Ryuichi;
- Nakayama, Kazuhisa;
- Wakatsuki, Soichi
Publication type:
Article
Structural basis for the accessory protein recruitment by the γ-adaptin ear domain.
Published in:
Nature Structural Biology, 2002, v. 9, n. 7, p. 527
By:
- Nogi, Terukazu;
- Shiba, Yoko;
- Kawasaki, Masato;
- Shiba, Tomoo;
- Matsugaki, Naohiro;
- Igarashi, Noriyuki;
- Suzuki, Mamoru;
- Kato, Ryuichi;
- Takatsu, Hiroyuki;
- Nakayama, Kazuhisa;
- Wakatsuki, Soichi
Publication type:
Article
Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target.
Published in:
Genes, 2020, v. 11, n. 12, p. 1468, doi. 10.3390/genes11121468
By:
- Sato, Dan;
- Hartuti, Endah Dwi;
- Inaoka, Daniel Ken;
- Sakura, Takaya;
- Amalia, Eri;
- Nagahama, Madoka;
- Yoshioka, Yukina;
- Tsuji, Naotoshi;
- Nozaki, Tomoyoshi;
- Kita, Kiyoshi;
- Harada, Shigeharu;
- Matsubayashi, Makoto;
- Shiba, Tomoo
Publication type:
Article
Identification of Plasmodium falciparum Mitochondrial Malate: Quinone Oxidoreductase Inhibitors from the Pathogen Box.
Published in:
Genes, 2019, v. 10, n. 6, p. 471, doi. 10.3390/genes10060471
By:
- Wang, Xinying;
- Miyazaki, Yukiko;
- Inaoka, Daniel Ken;
- Hartuti, Endah Dwi;
- Watanabe, Yoh-Ichi;
- Shiba, Tomoo;
- Harada, Shigeharu;
- Saimoto, Hiroyuki;
- Burrows, Jeremy Nicholas;
- Benito, Francisco Javier Gamo;
- Nozaki, Tomoyoshi;
- Kita, Kiyoshi
Publication type:
Article
Novel Characteristics of Mitochondrial Electron Transport Chain from Eimeria tenella.
Published in:
Genes, 2019, v. 10, n. 1, p. 29, doi. 10.3390/genes10010029
By:
- Matsubayashi, Makoto;
- Inaoka, Daniel Ken;
- Komatsuya, Keisuke;
- Hatta, Takeshi;
- Kawahara, Fumiya;
- Sakamoto, Kimitoshi;
- Hikosaka, Kenji;
- Yamagishi, Junya;
- Sasai, Kazumi;
- Shiba, Tomoo;
- Harada, Shigeharu;
- Tsuji, Naotoshi;
- Kita, Kiyoshi
Publication type:
Article
Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain
Published in:
FEBS Letters, 2005, v. 579, n. 24, p. 5385, doi. 10.1016/j.febslet.2005.08.076
By:
- Akutsu, Masato;
- Kawasaki, Masato;
- Katoh, Yohei;
- Shiba, Tomoo;
- Yamaguchi, Yoshiki;
- Kato, Ryuichi;
- Kato, Koichi;
- Nakayama, Kazuhisa;
- Wakatsuki, Soichi
Publication type:
Article
Structural basis for substrate specificity of l‐methionine decarboxylase.
Published in:
Protein Science: A Publication of the Protein Society, 2021, v. 30, n. 3, p. 663, doi. 10.1002/pro.4027
By:
- Okawa, Atsushi;
- Shiba, Tomoo;
- Hayashi, Masaya;
- Onoue, Yuki;
- Murota, Masaki;
- Sato, Dan;
- Inagaki, Junko;
- Tamura, Takashi;
- Harada, Shigeharu;
- Inagaki, Kenji
Publication type:
Article
Structural and mechanistic insights into homocysteine degradation by a mutant of methionine γ-lyase based on substrate-assisted catalysis.
Published in:
Protein Science: A Publication of the Protein Society, 2017, v. 26, n. 6, p. 1224, doi. 10.1002/pro.3158
By:
- Sato, Dan;
- Shiba, Tomoo;
- Yunoto, Shunsuke;
- Furutani, Kazuo;
- Fukumoto, Mitsuki;
- Kudou, Daizou;
- Tamura, Takashi;
- Inagaki, Kenji;
- Harada, Shigeharu
Publication type:
Article

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