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- Title
Preferential activation of peripheral blood Vγ9&sup+; γ/δ T cells by group A, B and C but not group D or F streptococci.
- Authors
Bender, A.; Kabelitz, D.
- Abstract
Previous studies have established that inactivated mycobacteria are potent and selective activators of Vγ9+/Vδ2+ human γ/δ T cells. Here we have analysed the proliferative response of human γ/δ T cells to five serologically distinct groups of streptococci. While heat-inactivated streptococci of all five serogroups tested (A, B, C, D and F) induced a strong proliferative response in peripheral blood mononuclear cells (PBMC), only groups A, B and C elicited a selective activation of Vγ9+ γ/δ T cells in 10 (serogroup B) or 11 (serogroups A and C) of 11 tested healthy individuals. In striking contrast, groups D and F streptococci failed to activate γ/δ T cells in nine of 11 donors and induced only a weak γ/δ T cell response in two additional individuals. Depletion of Vγ9+ T cells before culture completely eliminated all γ/δ T cell responses to streptococci. These data indicate that groups A, B and C (but not D or F) streptococci can be included in the growing list of selective ligands for Vγ9+/Vδ2+ human γ/δ T cells.
- Subjects
T cells; MYCOBACTERIA; STREPTOCOCCUS; SEROLOGY; BLOOD cells; IMMUNOLOGY
- Publication
Clinical & Experimental Immunology, 1992, Vol 89, Issue 2, p301
- ISSN
0009-9104
- Publication type
Article