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- Title
Failure of ADCC to predict HIV--associated disease progression or outcome in a haemophiliac cohort.
- Authors
Dalgleish, A.; Sinclair, A.; Steel, M; Beatson, D.; Ludlam, C.; Habeshaw, I.
- Abstract
Antibody-dependent cell-mediated cytotoxicity (ADCC) has been described in a number of virus infections and occurs in HIV infection. In spite of numerous studies on the ability of HIV-positive sera to mediate ADCC, it remains unclear whether ADCC has any functional significance. Here we examine serial serum samples from a cohort of haemophilia patients who became infected from a common source in 1984, and show that there is no significant difference in ADCC values between those who remained asymptomatic and those who progressed to disease. This study does not compare effector cell function and clinical status and does not exclude activity against different target cell lineages in vivo.
- Subjects
IMMUNOGLOBULINS; HIV infections; LENTIVIRUS diseases; HAEMOPHILUS diseases; GRAM-negative bacterial diseases; CHANCROID
- Publication
Clinical & Experimental Immunology, 1990, Vol 81, Issue 1, p5
- ISSN
0009-9104
- Publication type
Article