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- Title
Therapy of a fatal murine cytomegalovirus infection with thymic humoral factor (THF-y2) treated immune spleen cells.
- Authors
Rager-Zisman, B.; Zuckerman, F.; Benharroch, D.; Pecht, M.; Burstein, Y.; Trainin, N.
- Abstract
Infection of mice with murine cytomegalovirus (CMV) presents a model for the study of the role of the immune system in the pathogenesis of human CMV. We performed adoptive transfer experiments to evaluate the prospects for enhancing the anti-viral potential of murine CMV immune spleen cells by THF-γ2. Adult BALB/e mice resistant to murine CMV become highly susceptible following immunosuppression by cyclophosphamide. Recipient mice were injected with murine CMV and cyclophosphamide concomitantly, and 24 h later adoptive transfers of syngeneic immune spleen cells were performed. We showed that passive transfers of murine CM V immune spleen cells prevented the development of a fatal disease in 38%, of the recipient mice. Daily injections of murine CMV immune donor mice with THF-γ2 enhanced considerably (93%) the therapeutic potential of virus-specific immune cells. These experiments provide direct evidence for the antiviral capacity of THF-γ2 through its immunomodulatory effect on immune T cells.
- Subjects
CYTOMEGALOVIRUSES; MICE; IMMUNE system; ANTIVIRAL agents; IMMUNOSUPPRESSION; T cells
- Publication
Clinical & Experimental Immunology, 1990, Vol 79, Issue 2, p246
- ISSN
0009-9104
- Publication type
Article
- DOI
10.1111/j.1365-2249.1990.tb05186.x