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- Title
Sera of Schistosoma japonicum-infected patients cross-react with diagnostic 31/32 kD proteins of S. mansoni.
- Authors
Shi, A. Ruppel Y. E.; Wei, D. X.; Diesfeld, H. J.
- Abstract
Schistosoma mansoni adult worm antigens were tested for cross-react ions with sera obtained from patients infected with .S. Japonicum. The sera consistently recognized a doublet of bands, in immunoblots, which had molecular weights of approximately 31 and 32 kilodalions (kD). This reaction was found to be markedly reduced with sera of patients who had received chemotherapy and who had a low risk of reinfection. Sera obtained from uninfected persons or from patients infected with other parasites never reacted with the antigen doublet. Schistosoma japonicum-infected mice produced antibodies during prepotency which predominantly recognized antigens of this molecular weight range in immunoblots performed with S. mansoni or .S. japonicum proteins. Sera from, S. mansoni infected patients with a high specificity for the diagnostic 31/32 kD anligen cross-reacted with a corresponding component also in S. japonicum worms. Immunofluorescence assays performed with sera of sehistosomiasis japonica patients confirmed earlier results localizing the diagnostic 31,32 kD antigens in the gut of-S, mansoni. These cross-reaeiing 31 32 kD .S\mansoni protein antigens may be applied for the immunodiagnosis of schistosomiasis japonica.
- Subjects
SCHISTOSOMA; SCHISTOSOMATIDAE; BLOOD plasma; CRYOSCOPY; DRUG therapy; IMMUNOCYTOCHEMISTRY
- Publication
Clinical & Experimental Immunology, 1987, Vol 69, Issue 2, p291
- ISSN
0009-9104
- Publication type
Article