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- Title
An unusual variant of T-CLL: evidence for the existence of a hitherto unrecognized T cell subset.
- Authors
Moss, Vivienne E.; Miedema, F.; Matutes, Estela; Terpstra, F.; Brownell, Alison; Brozovic, Misha; Catovsky, D.
- Abstract
A case of T-cell chronic lymphocytic leukaemia (T-CLL) with an unusual mature membrane phenotype: E+, CD3+, CD4+, CD8-, M1+, Leu-15+, Fcγ+, is described. The cells were large granular lymphocytes with slight immature features. Functionally these cells lacked helper, suppressor and NK activity but possessed normal levels of K activity. These findings demonstrate several features not previously described in T-CLL; (a) the coexpression of the antigens detected by T4, M1 and Leu-15 (b) the presence of Feγ receptors on CD4+ lymphocytes and (c) the lack of NK activity in M1+, Feγ + cells. This study broadens the known heterogeneity of T-CLL and suggests the existence of a hitherto unrecognized normal T-lymphocyte subset with the same functional and phenotypic characteristics as in the ease described here.
- Subjects
LYMPHOCYTIC leukemia; LYMPHOPROLIFERATIVE disorders; T cells; LYMPHOCYTES; LEUCOCYTES; BLOOD cells
- Publication
Clinical & Experimental Immunology, 1986, Vol 63, Issue 2, p303
- ISSN
0009-9104
- Publication type
Article