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- Title
Comparative genomics enabled the isolation of theR3alate blight resistance gene in potato.
- Authors
Huang, Sanwen; van der Vossen, Edwin A.G.; Kuang, Hanhui; Vleeshouwers, Vivianne G.A.A.; Zhang, Ningwen; Borm, Theo J.A.; van Eck, Herman J.; Baker, Barbara; Jacobsen, Evert; Visser, Richard G.F.
- Abstract
Comparative genomics provides a tool to utilize the exponentially increasing sequence information from model plants to clone agronomically important genes from less studied crop species. Plant disease resistance (R) loci frequently lack synteny between related species of cereals and crucifers but appear to be positionally well conserved in the Solanaceae. In this report, we adopted a local RGA approach using genomic information from the model Solanaceous plant tomato to isolateR3a, a potato gene that confers race-specific resistance to the late blight pathogenPhytophthora infestans.R3ais a member of theR3complex locus on chromosome 11. Comparative analyses of theR3complex locus with the correspondingI2complex locus in tomato suggest that this is an ancient locus involved in plant innate immunity against oomycete and fungal pathogens. However, theR3complex locus has evolved after divergence from tomato and the locus has experienced a significant expansion in potato without disruption of the flanking colinearity. This expansion has resulted in an increase in the number ofRgenes and in functional diversification, which has probably been driven by the co-evolutionary history betweenP. infestansand its host potato. Constitutive expression was observed for theR3agene, as well as some of its paralogues whose functions remain unknown.
- Subjects
GENOMICS; POTATOES; GENES; CROPS; PLANT diseases; AGRICULTURAL pests
- Publication
Plant Journal, 2005, Vol 42, Issue 2, p251
- ISSN
0960-7412
- Publication type
Article
- DOI
10.1111/j.1365-313X.2005.02365.x