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- Title
Activity-dependent activation of presynaptic protein kinase C mediates post-tetanic potentiation.
- Authors
Brager, Darrin H; Cai, Xiang; Thompson, Scott M
- Abstract
Vesicle exocytosis is mediated by the complex interaction between synaptic vesicle and plasma membrane proteins, many of which are substrates for protein kinases[SUP1-3]. Exogenous protein kinase activators increase release probability at several mammalian CNS synapses[SUP4-6], but the physiological conditions under which presynaptic protein kinases become activated are not known. We report here that calcium/phospholipiddependent protein kinase C (PKC) is activated by highfrequency stimulation and mediates post-tetanic potentiation (PTP) in the rat hippocampus.
- Subjects
EXOCYTOSIS; CELL membranes; PROTEIN kinases; SYNAPSES
- Publication
Nature Neuroscience, 2003, Vol 6, Issue 6, p551
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn1067