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- Title
Transcriptional activity of blood-and cerebrospinal fluid–derived <i>nef</i>/long-terminal repeat sequences isolated from a slow progressor infected with <i>nef</i>-deleted human immunodeficiency virus type 1 (HIV-1) who developed HIV-associated dementia
- Authors
Churchill, Melissa; Figueiredo, Anna; Cowley, Daniel; Gray, Lachlan; Purcell, Damian; Sullivan, John; McPhee, Dale; Wesselingh, Steven; Brew, Bruce; Gorry, Paul
- Abstract
The authors studied the transcriptional activity of blood-and cerebrospinal fluid (CSF)-derived nef /long-terminal repeat (LTR) sequences isolated from a slow progressor infected with nef -deleted human immunodeficiency virus type 1 (HIV-1) who developed HIV-associated dementia (HIVD). The transcriptional activity of CSF-derived nef /LTR clones isolated during HIVD was up to 4.5-fold higher than blood-derived clones isolated before and during HIVD when tested under basal, phorbol 12-myristate 13-acetate-(PMA-), and Tat-activated conditions, and was associated with the presence of duplicated nuclear factor (NF)-κB and specificity factor-1 (Sp-1) binding sites coupled with a truncated nef sequence, increased replication capacity, and high CSF viral load. Thus, nef and LTR mutations that augment transcription may contribute to neuropathogenesis of nef -deleted HIV-1. Journal of NeuroVirology (2006) 12 , 219–228.
- Subjects
NEUROVIROLOGY; CEREBROSPINAL fluid; DEMENTIA; NEUROBEHAVIORAL disorders; HIV; TROPISMS
- Publication
Journal of NeuroVirology, 2006, Vol 12, Issue 3, p219
- ISSN
1355-0284
- Publication type
Article
- DOI
10.1080/13550280600827369