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- Title
Merlot wine and the metabolic and cardiovascular changes in LDLR - / - mice.
- Authors
Alves dos Anjos, Jander; Hipólito da Silva, Letícia Albano; Pereira Marinho, Rafael; Mesquita Oliveira, Wilson Roberto; Bitencourt Santos, Gersika; de Souza Carvalho, Maria das Graças; Vilas Boas, Brígida Monteiro; Manke Nachtigall, Aline; Peregrino, Isabela; Sancineto da Silva Nunes, Jefferson Luís; Helena Pereira, Flávia; Dias Garcia, José Antônio
- Abstract
Dyslipidemia is considered a risk factor for the development of insulin resistance and cardiovascular diseases, such as left ventricular hypertrophy and remodeling of the arterial wall. Resveratrol, present in grapes, has been studied as a possible mediator of cardiovascular protection. The present study aimed to evaluate the effect of red wine from the Merlot grape (Vitis vinifera L.) on dyslipidemia and its involvement in male mice, knockout for the LDL receptor gene (LDLR-/-). The mice were divided into 4 experimental groups: Group S received standard rodent food; Group SV received standard feed for rodents and wine; Group HL received high fat diet; Group HLV received hyperlipidic food and wine orally for 60 days. All animals received water and food ad libitum during this period. After this period, they remained fasting and were then anesthetized. Blood was collected for serum analysis of triglycerides, total cholesterol, and its fractions (HDL and VLDL), C-reactive protein, glucose, and insulin to compare the data. Morphometric and histological analyzes of the left ventricle and abdominal aorta were also performed. It was found that Merlot red wine has antidyslipidemic effects on genetic dyslipidemia, associated with food, partially preventing insulin resistance, hyperinsulinemia and increased CRP; as well as cardiovascular effect, partially preventing LVH and arterial remodeling.
- Subjects
MERLOT; RED wines; LEFT ventricular hypertrophy; HIGH-fat diet; ANALYSIS of triglycerides; LOW density lipoprotein receptors; VITIS vinifera; SYRAH
- Publication
Revista Ciência e Natura, 2023, Vol 45, p1
- ISSN
0100-8307
- Publication type
Article
- DOI
10.5902/2179460X68358