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- Title
Effects of soybean product intake on fasting and postload hyperglycemia and type 2 diabetes in Japanese men with high body mass index: The Saku Study.
- Authors
Tatsumi, Yukako; Morimoto, Akiko; Deura, Kijyo; Mizuno, Shoichi; Ohno, Yuko; Watanabe, Shaw
- Abstract
Aims/Introduction The inverse association between soybean intake and type 2 diabetes mellitus has been reported. We investigated the effects of soybean product intake on the incidence of type 2 diabetes mellitus considering fasting and postload hyperglycemia. Materials and Methods The present 4-year, cohort study included 1,738 men and 1,301 women, aged 30-69 years, without diabetes mellitus at baseline who underwent comprehensive medical check-ups between April 2006 and March 2007 at Saku Central Hospital. Participants were stratified by sex and body mass index ( BMI), and further classified into three groups based on soybean product intake: group 1 (0-1 time/week), group 2 (2-3 times/week) and group 3 (four or more times per week). Participants underwent annual standard 75-g oral glucose tolerance testing during follow-up periods until March 2011. Main outcomes were incidence of fasting hyperglycemia, postload hyperglycemia and type 2 diabetes mellitus. Results During 10,503 person-years of follow up, 204 participants developed type 2 diabetes mellitus, including 61 who developed fasting hyperglycemia and 147 who developed postload hyperglycemia. Among men with a high BMI, group 3 had significantly lower risk for the incidence of type 2 diabetes mellitus, fasting hyperglycemia and postload hyperglycemia than group 1, and multivariable-adjusted hazard ratios and 95% confidence intervals were 0.44 (0.22-0.89), 0.36 (0.15-0.96) and 0.40 (0.18-0.92), respectively. Similar results were not observed among men with low BMI or women. Conclusions Soybean product intake prevented fasting and postload hyperglycemia and type 2 diabetes mellitus in men with a high BMI. Further long-term observation is necessary.
- Subjects
SOYBEAN products; FASTING; HYPERGLYCEMIA; PEOPLE with diabetes; JAPANESE people; BODY mass index; FOLLOW-up studies (Medicine); COHORT analysis; DISEASES
- Publication
Journal of Diabetes Investigation, 2013, Vol 4, Issue 6, p626
- ISSN
2040-1116
- Publication type
Article
- DOI
10.1111/jdi.12100