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- Title
MicroRNA-338-3p suppresses tumor growth of esophageal squamous cell carcinoma in vitro and in vivo.
- Authors
XINYU LI; ZHIHONG LI; GUIYUN YANG; ZHENXIANG PAN
- Abstract
Accumulating evidence has shown that microRNAs (miRNAs) are aberrantly expressed in human esophageal squamous cell carcinoma (ESCC) and are crucial in tumorigenesis, among which miR-338-3p has been examined to be downregulated in patients with ESCC. However, the role of miR-338-3p in ESCC remains to be elucidated. In the present study, the role of miR-338-3p on the growth and survival of an ESCC cell line was determined with several in vitro approaches and in nude mouse models. It was determined that miR-338-3p expression was frequently downregulated in ESCC tissue compared with corresponding adjacent non-tumor tissue, and that its expression was significantly correlated with tumor stage and metastasis. Overexpression of miR-338-3p in ESCC cells suppressed cell proliferation, colony formation, migration and invasion, and induced cell arrest at the G0/G1 stage and cell apoptosis in vitro. In addition, it was demonstrated that overexpression of miR-338-3p significantly suppresses tumor growth of xenograft tumors in mice (P<0.05). These findings revealed that miR-338-3p may act as a tumor suppressor in ESCC, and its dysregulation may be involved in the initiation and development of human ESCC. In addition, it was suggested that miR-338-3p may be a potential therapeutic agent for treatment of ESCC.
- Subjects
ESOPHAGEAL stenosis; CANCER treatment; SQUAMOUS cell carcinoma; MICRORNA; TUMOR growth prevention; CELL migration; CANCER invasiveness; IN vitro studies; CELL cycle; PREVENTION; THERAPEUTICS
- Publication
Molecular Medicine Reports, 2015, Vol 12, Issue 3, p3951
- ISSN
1791-2997
- Publication type
Article
- DOI
10.3892/mmr.2015.3820