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- Title
PAX-5 positive anaplastic large cell lymphoma presenting by dysphagia; a case report.
- Authors
Azarpira, Negar; Safaie, Akbar; Monabati, Ahmad; Hosseinzadeh, Masudd; Noori, Sadat; Moini, Maryam; Rahimi, Alireza; Heidari, Tahereh; Rahsaz, Marjan
- Abstract
Anaplastic large cell lymphoma (ALCL) is a distinct pathologic entity with characteristic morphologic, immunophenotypic and cytogenetic features. Obstructive symptoms are rare presentation of ALCL. We report a 16-year-old boy who initially presented with dysphagia. Upper gastrointestinal endoscopy revealed severe stenosis with an infiltrative process starting from 24 cm of incisors in lower esophagus Esophageal mucosal biopsy demonstrated lymphomatous involvement that ancillary tests confirmed the diagnosis of ALCL, ALK (kinase-positive), and PAX5 positive. The patient responded to CHOP-based chemotherapy. This case illustrated an unusual presentation of primary Non Hodgkin lymphoma of esophagus.
- Subjects
DOXORUBICIN; ETOPOSIDE; VINCRISTINE; PREDNISONE; CYCLOPHOSPHAMIDE; ESOPHAGEAL stenosis; BIOPSY; CANCER chemotherapy; DEGLUTITION disorders; LYMPHOMAS; PROTEIN-tyrosine kinases; PROTEINS; T-cell lymphoma; ENDOSCOPIC gastrointestinal surgery; DIAGNOSIS; THERAPEUTICS
- Publication
Gastroenterology & Hepatology from Bed to Bench, 2017, Vol 10, Issue 4, p332
- ISSN
2008-2258
- Publication type
Article