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- Title
Rotaviruses: From Pathogenesis to Disease Control—A Critical Review.
- Authors
Omatola, Cornelius A.; Olaniran, Ademola O.
- Abstract
Since their first recognition in human cases about four decades ago, rotaviruses have remained the leading cause of acute severe dehydrating diarrhea among infants and young children worldwide. The WHO prequalification of oral rotavirus vaccines (ORV) a decade ago and its introduction in many countries have yielded a significant decline in the global burden of the disease, although not without challenges to achieving global effectiveness. Poised by the unending malady of rotavirus diarrhea and the attributable death cases in developing countries, we provide detailed insights into rotavirus biology, exposure pathways, cellular receptors and pathogenesis, host immune response, epidemiology, and vaccination. Additionally, recent developments on the various host, viral and environmental associated factors impacting ORV performance in low-and middle-income countries (LMIC) are reviewed and their significance assessed. In addition, we review the advances in nonvaccine strategies (probiotics, candidate anti-rotaviral drugs, breastfeeding) to disease prevention and management.
- Subjects
ROTAVIRUSES; PREVENTIVE medicine; GLOBAL burden of disease; ROTAVIRUS vaccines; MIDDLE-income countries; ORAL vaccines
- Publication
Viruses (1999-4915), 2022, Vol 14, Issue 5, p875
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v14050875