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- Title
Limosilactobacillus fermentum Strains with Claimed Probiotic Properties Exert Anti-oxidant and Anti-inflammatory Properties and Prevent Cardiometabolic Disorder in Female Rats Fed a High-Fat Diet.
- Authors
de Luna Freire, Micaelle Oliveira; do Nascimento, Luciana Caroline Paulino; de Oliveira, Kataryne Árabe Rimá; de Oliveira, Alisson Macário; dos Santos Lima, Marcos; Napoleão, Thiago Henrique; da Costa Silva, João Henrique; Lagranha, Cláudia Jacques; de Souza, Evandro Leite; de Brito Alves, José Luiz
- Abstract
This study assessed the effects of a mixed formulation containing Limosilactobacillus (L.) fermentum 139, L. fermentum 263, and L. fermentum 296 on cardiometabolic parameters, inflammatory markers, short-chain fatty acid (SCFA) fecal contents, and oxidative stress in colon, liver, heart, and kidney tissues of female rats fed a high-fat diet (HFD). Female Wistar rats were allocated into control diet (CTL, n = 6), HFD (n = 6), and HFD receiving L. fermentum formulation (HFD-LF, n = 6). L. fermentum formulation (1 × 109 CFU/mL of each strain) was administered two twice a day for 4 weeks. Administration of L. fermentum increased acetate and succinate fecal contents and reduced hyperlipidemia and hyperglycemia in rats fed a HFD (p < 0.05). Administration of L. fermentum decreased low-grade inflammation and improved antioxidant capacity along the gut, liver, heart, and kidney tissues in female rats fed a HFD (p < 0.05). Administration of L. fermentum prevented dyslipidemia, inflammation, and oxidative stress in colon, liver, heart, and kidney in female rats fed a HFD.
- Publication
Probiotics & Antimicrobial Proteins, 2023, Vol 15, Issue 3, p601
- ISSN
1867-1306
- Publication type
Article
- DOI
10.1007/s12602-021-09878-1