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- Title
Isolation, Characterization and Antiproliferative Activity of Secondary Metabolites from Tanacetum alyssifolium (Bornm.) Grierson.
- Authors
Köksal, Ekrem; Ulutaş, Yakup; Şimşek, Samed; Bayraktar, Taha; Altay, Ahmet; Çatır, Mustafa; Demirtaş, İbrahim; Tüfekçi, Ali Rıza; Kandemir, Ali; Alp, Cemalettin; Alemdar, Mohammed B. Anwer; Akşit, Hüseyin
- Abstract
Secondary metabolites of Tanacetum alyssifolium (Bornm.) Grierson (Asteraceae) were investigated for the first time. Thirteen compounds including axillarin (1), Luteolin-7-O-β-glucoside (8) and rutin (13) as flavonoids, fraxetin (7), isofraxidin (9), isofraxidin-7-O-glucoside (11) and fraxidin (12) as coumarins, tatridin A (2), altissin (3), tamirin (4) and tanachin (5) as sesquiterpene lactones and 2,4-dihydroxy-6-methoxy acetophenone (6) and picein (10) as acetophenone derivatives were isolated from the methanol extract of the species. The structures of all isolated compounds were elucidated by 1D and 2D-NMR techniques and by comparing with the literature data. In addition, in vitro cytotoxic activity of all isolated compounds was evaluated against breast cancer MCF-7 cell line by XTT assay. Sesquiterpene lactones; tatridin A (2), tamirin (4) and tanachin (5) were found to be the most cytotoxic molecules against MCF-7 cell line.
- Subjects
METABOLITES; SESQUITERPENE lactones; FLAVONOID glycosides; ACETOPHENONE derivatives; CELL lines; COUMARINS
- Publication
Records of Natural Products, 2021, Vol 15, Issue 2, p122
- ISSN
1307-6167
- Publication type
Article
- DOI
10.25135/rnp.201.20.07.1702