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- Title
Investigation of the antifungal effects of curcumin against nystatin-resistant Candida albicans.
- Authors
Hajifathali, Soha; Lesan, Simin; Lotfali, Ensieh; Salimi-Sabour, Ebrahim; Khatibi, Mandana
- Abstract
Background: Emergence of nystatin-resistant Candida albicans (C. albicans) strains has raised some concerns in the recent years. Recent scientific evidence proves that turmeric, especially curcumin, has anti-inflammatory and anti-fungal activity. The aim of this study was the investigation of the antifungal effects of curcumin against nystatin-resistant C. albicans. Materials and Methods: This in vitro, experimental study evaluated standard-strain (ATCC 16201) and 10 nystatin-resistant C. albicans strains. The antifungal activity and minimum inhibitory concentration (MIC) of curcumin were evaluated using the CLSI-M27-A3, and the MIC of curcumin was compared with that of nystatin. The results were analyzed using the one-way ANOVA. Results: The MIC of curcumin was 15.6, 32.25, 15.6, 7.8, 32.25, 15.6, 15.6, 15.6, 32.25, and 15.6 µg/mL for the 10 resistant strains and 62.5 µg/mL for the standard strain of C. albicans. Curcumin in the above-mentioned concentrations significantly inhibited the proliferation of nystatin-resistant C. albicans strains (P < 0.001). Conclusion: According to this research, it was shown that curcumin with MIC value of 7.8--32.25 µg/mL has inhibitory effects on nystatin-resistant C. albicans strains.
- Subjects
ANTIFUNGAL agents; IN vitro studies; EXPERIMENTAL design; ANALYSIS of variance; CURCUMIN; NYSTATIN; CELL proliferation; CANDIDA albicans; DRUG resistance in microorganisms; PHARMACODYNAMICS
- Publication
Dental Research Journal, 2023, Vol 20, Issue 4, p1
- ISSN
1735-3327
- Publication type
Article