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- Title
Ubiquitin pathway and ovarian cancer.
- Authors
Rao, Z.; Ding, Y.
- Abstract
The ubiquitin-proteasome pathway is a common cellular process in eukaryotic tissue. Ubiquitin binds to proteins and tags them for destruction; this tagging directs proteins to the proteosome in the cell that degrades and recycles unneeded proteins. The ubiquitin-proteasome pathway plays an important role in the regulation of cellular proteins with respect to cell cycle control, transcription, apoptosis, cell adhesion, angiogenesis, and tumour growth. This review article discusses the various ways that the ubiquitin pathway is involved in ovarian cancer, such as modulating the ovarian-cancer- related gene BRCA1 and tumour suppressor p53, and interfering with the ERK pathway, the cyclin-dependent cell cycle regulation process, and ERBB2 gene expression.
- Subjects
UBIQUITIN structure; PROTEASOME regulation; EUKARYOTIC cells; TUMOR suppressor proteins; NEOVASCULARIZATION; OVARIAN cancer
- Publication
Current Oncology, 2012, Vol 19, Issue 6, p324
- ISSN
1198-0052
- Publication type
Article
- DOI
10.3747/co.19.1175