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A combined physiologically‐based pharmacokinetic and quantitative systems pharmacology model for modeling amyloid aggregation in Alzheimer's disease.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 4, p. 444, doi. 10.1002/psp4.12912
By:
- Geerts, Hugo;
- Walker, Mike;
- Rose, Rachel;
- Bergeler, Silke;
- van der Graaf, Piet H.;
- Schuck, Edgar;
- Koyama, Akihiko;
- Yasuda, Sanae;
- Hussein, Ziad;
- Reyderman, Larisa;
- Swanson, Chad;
- Cabal, Antonio
Publication type:
Article
Safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel γ-secretase modulator, E2212, in healthy human subjects.
Published in:
2014
By:
- Yu, Yanke;
- Logovinsky, Veronika;
- Schuck, Edgar;
- Kaplow, June;
- Chang, Min-kun;
- Miyagawa, Takehiko;
- Wong, Nancy;
- Ferry, Jim
Publication type:
Journal Article
Safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel γ-secretase modulator, E2212, in healthy human subjects.
Published in:
Journal of Clinical Pharmacology, 2014, v. 54, n. 5, p. 528, doi. 10.1002/jcph.249
By:
- Yu, Yanke;
- Logovinsky, Veronika;
- Schuck, Edgar;
- Kaplow, June;
- Chang, Min‐kun;
- Miyagawa, Takehiko;
- Wong, Nancy;
- Ferry, Jim
Publication type:
Article
Effect of Simulated Microgravity on the Disposition and Tissue Penetration of Ciprofloxacin in Healthy Volunteers.
Published in:
Journal of Clinical Pharmacology, 2005, v. 45, n. 7, p. 822, doi. 10.1177/0091270005276620
By:
- Schuck, Edgar L.;
- Grant, Maria;
- Derendorf, Hartmut
Publication type:
Article
Physiological, Pharmacokinetic, and Pharmacodynamic Changes in Space.
Published in:
Journal of Clinical Pharmacology, 2004, v. 44, n. 8, p. 837
By:
- Annemarie Graebe;
- Edgar L. Schuck;
- Petra Lensing;
- Lakshmi Putcha;
- Hartmut Derendorf
Publication type:
Article
Preclinical Pharmacokinetic/Pharmacodynamic Modeling and Simulation in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.
Published in:
AAPS Journal, 2015, v. 17, n. 2, p. 462, doi. 10.1208/s12248-014-9716-2
By:
- Schuck, Edgar;
- Bohnert, Tonika;
- Chakravarty, Arijit;
- Damian-Iordache, Valeriu;
- Gibson, Christopher;
- Hsu, Cheng-Pang;
- Heimbach, Tycho;
- Krishnatry, Anu;
- Liederer, Bianca;
- Lin, Jing;
- Maurer, Tristan;
- Mettetal, Jerome;
- Mudra, Daniel;
- Nijsen, Marjoleen;
- Raybon, Joseph;
- Schroeder, Patricia;
- Schuck, Virna;
- Suryawanshi, Satyendra;
- Su, Yaming;
- Trapa, Patrick
Publication type:
Article
Clinical Drug–Drug Interaction Potential of BFE1224, Prodrug of Antifungal Ravuconazole, Using Two Types of Cocktails in Healthy Subjects.
Published in:
CTS: Clinical & Translational Science, 2018, v. 11, n. 5, p. 477, doi. 10.1111/cts.12557
By:
- Ishii, Yasuyuki;
- Ito, Yuko;
- Matsuki, Shunji;
- Sanpei, Kasumi;
- Ogawa, Osamu;
- Takeda, Kenji;
- Schuck, Edgar L.;
- Uemura, Naoto
Publication type:
Article
Safety, pharmacokinetics and pharmacodynamics of four-hour intravenous infusions of eritoran in healthy Japanese and Caucasian men.
Published in:
Innate Immunity, 2012, v. 18, n. 6, p. 793, doi. 10.1177/1753425912441845
By:
- Aikawa, Naoki;
- Okubo, Yoshio;
- Lynn, Melvyn;
- Rossignol, Daniel P;
- Wong, Y Nancy;
- Schuck, Edgar;
- Kitahara, Yasumi;
- Nakano, Tomohisa;
- Sivak, Olena;
- Wasan, Kishor M;
- Nagy, Christa;
- Yen, Mark
Publication type:
Article
Physiologically‐based pharmacokinetic modeling to predict drug interactions of lemborexant with CYP3A inhibitors.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 5, p. 455, doi. 10.1002/psp4.12606
By:
- Ueno, Takashi;
- Miyajima, Yukiko;
- Landry, Ishani;
- Lalovic, Bojan;
- Schuck, Edgar
Publication type:
Article
Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 1, p. 5, doi. 10.1002/psp4.12478
By:
- Geerts, Hugo;
- Wikswo, John;
- Graaf, Piet H.;
- Bai, Jane P.F.;
- Gaiteri, Chris;
- Bennett, David;
- Swalley, Susanne E.;
- Schuck, Edgar;
- Kaddurah‐Daouk, Rima;
- Tsaioun, Katya;
- Pelleymounter, Mary
Publication type:
Article
Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 11, p. 777, doi. 10.1002/psp4.12463
By:
- Bradshaw, Erica L.;
- Spilker, Mary E.;
- Zang, Richard;
- Bansal, Loveleena;
- He, Handan;
- Jones, Rhys D.O.;
- Le, Kha;
- Penney, Mark;
- Schuck, Edgar;
- Topp, Brian;
- Tsai, Alice;
- Xu, Christine;
- Nijsen, Marjoleen J.M.A.;
- Chan, Jason R.
Publication type:
Article
Recommendations for the Design of Clinical Drug–Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically‐Based Pharmacokinetic Model.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 9, p. 685, doi. 10.1002/psp4.12449
By:
- Chen, Yuan;
- Cabalu, Tamara D.;
- Callegari, Ernesto;
- Einolf, Heidi;
- Liu, Lichuan;
- Parrott, Neil;
- Peters, Sheila Annie;
- Schuck, Edgar;
- Sharma, Pradeep;
- Tracey, Helen;
- Upreti, Vijay V.;
- Zheng, Ming;
- Zhu, Andy Z.X.;
- Hall, Stephen D.
Publication type:
Article
Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 3, p. 135, doi. 10.1002/psp4.12282
By:
- Nijsen, Marjoleen J. M. A.;
- Wu, Fan;
- Bansal, Loveleena;
- Bradshaw‐Pierce, Erica;
- Chan, Jason R.;
- Liederer, Bianca M.;
- Mettetal, Jerome T.;
- Schroeder, Patricia;
- Schuck, Edgar;
- Tsai, Alice;
- Xu, Christine;
- Chimalakonda, Anjaneya;
- Le, Kha;
- Penney, Mark;
- Topp, Brian;
- Yamada, Akihiro;
- Spilker, Mary E.
Publication type:
Article
Eribulin shows high concentration and long retention in xenograft tumor tissues.
Published in:
2017
By:
- Sugawara, Michiko;
- Condon, Krista;
- Liang, Earvin;
- DesJardins, Christopher;
- Schuck, Edgar;
- Kusano, Kazutomi;
- Lai, W.;
- Lai, W George
Publication type:
journal article
Pharmacokinetic/pharmacodynamic drug–drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting drugs.
Published in:
British Journal of Clinical Pharmacology, 2018, v. 84, n. 5, p. 952, doi. 10.1111/bcp.13517
By:
- Nomoto, Maiko;
- Zamora, Cynthia A.;
- Schuck, Edgar;
- Boyd, Peter;
- Chang, Min‐Kun;
- Aluri, Jagadeesh;
- Siu, Y. Amy;
- Lai, W. George;
- Yasuda, Sanae;
- Ferry, Jim;
- Rege, Bhaskar
Publication type:
Article
P4‐657: POPULATION PHARMACOKINETIC/PHARMACODYNAMIC ANALYSES OF BAN2401 IN PATIENTS WITH EARLY ALZHEIMER'S DISEASE: CORRELATION OF BAN2401 EXPOSURE, PET STANDARD UPTAKE VALUE RATIO, AND COGNITIVE OUTCOMES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1582, doi. 10.1016/j.jalz.2019.09.023
By:
- Schuck, Edgar L.;
- Reyderman, Larisa;
- Hayato, Seiichi;
- Takenaka, Osamu;
- Swanson, Chad J.;
- Lai, Robert YK.;
- Hussein, Ziad;
- Ferry, Jim
Publication type:
Article
P1‐055: E2027, A NOVEL PHOSPHODIESTERASE‐9 (PDE9) INHIBITOR IN DEVELOPMENT FOR TREATMENT OF DEMENTIA WITH LEWY BODIES (DLB), SHOWED NO CLINICALLY SIGNIFICANT DRUG INTERACTION WITH DILTIAZEM.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P289, doi. 10.1016/j.jalz.2018.06.057
By:
- Landry, Ishani;
- Lai, Robert YK.;
- Boyd, Peter;
- Aluri, Jagadeesh;
- Chang, Min-Kun;
- Schuck, Edgar L.;
- Luthman, Johan
Publication type:
Article
O1‐12‐06: PHASE 1 MULTIPLE ASCENDING DOSE (MAD) STUDY OF PHOSPHODIESTERASE‐9 INHIBITOR E2027: CONFIRMATION OF TARGET ENGAGEMENT AND SELECTION OF PHASE 2 DOSE IN DEMENTIA WITH LEWY BODIES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P251, doi. 10.1016/j.jalz.2018.06.2401
By:
- Landry, Ishani;
- Lai, Robert YK.;
- Boyd, Peter;
- Aluri, Jagadeesh;
- Chang, Min-Kun;
- Ino, Mitsuhiro;
- Horie, Kanta;
- Schuck, Edgar L.;
- Luthman, Johan
Publication type:
Article
POPULATION PHARMACOKINETIC-PHARMACODYNAMIC (PK/PD) MODELING OF E2027, A SELECTIVE PHOSPHODIESTERASE-9 (PDE9) INHIBITOR, FOLLOWING SINGLE ASCENDING ORAL DOSES IN HEALTHY VOLUNTEERS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P258, doi. 10.1016/j.jalz.2017.06.123
By:
- Schuck, Edgar L.;
- Lai, Robert Y.K.;
- Aluri, Jagadeesh;
- Hussein, Ziad;
- Ino, Mitsuhiro;
- Kotani, Sadaharu;
- Chang, Min-Kun;
- Savant-Landry, Ishani;
- Luthman, Johan
Publication type:
Article
PHASE 1 INVESTIGATION INTO THE SAFETY, TOLERABILITY, PHARMACOKINETICS (PK) AND PHARMACODYNAMICS (PD) OF E2027, A SELECTIVE PHOSPHODIESTERASE-9 (PDE9) INHIBITOR.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P574, doi. 10.1016/j.jalz.2017.07.194
By:
- Lai, Robert Y.K.;
- Gordon, Robert;
- Chang, Min-Kun;
- Boyd, Peter;
- Savant-Landry, Ishani;
- Aluri, Jagadeesh;
- Ino, Mitsuhiro;
- Horie, Kanta;
- Kotani, Sadaharu;
- Schuck, Edgar L.;
- Luthman, Johan
Publication type:
Article
E2012, a novel gamma-secretase modulator, decreases plasma amyloid-beta (Aβ) levels in humans
Published in:
2010
By:
- Nagy, Christa;
- Schuck, Edgar;
- Ishibashi, Akira;
- Nakatani, Yosuke;
- Rege, Bhaskar;
- Logovinsky, Veronika
Publication type:
Abstract
Perampanel and pregnancy.
Published in:
Epilepsia (Series 4), 2021, v. 62, n. 3, p. 698, doi. 10.1111/epi.16821
By:
- Vazquez, Blanca;
- Tomson, Torbjörn;
- Dobrinsky, Cindy;
- Schuck, Edgar;
- O'Brien, Terence J.
Publication type:
Article
Changes in perampanel levels during de‐induction: Simulations following carbamazepine discontinuation.
Published in:
Acta Neurologica Scandinavica, 2020, v. 142, n. 2, p. 131, doi. 10.1111/ane.13286
By:
- Schuck, Edgar;
- Ferry, Jim;
- Gidal, Barry;
- Hussein, Ziad
Publication type:
Article
Pharmacokinetic characterization of a natural product-inspired novel MEK1 inhibitor E6201 in preclinical species.
Published in:
Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 229, doi. 10.1007/s00280-011-1687-8
By:
- Kumar, Vipul;
- Schuck, Edgar;
- Pelletier, Robert;
- Farah, Nadia;
- Condon, Krista;
- Ye, Meng;
- Rowbottom, Christopher;
- King, Belinda;
- Zhang, Zhi-Yi;
- Saxton, Philip;
- Wong, Y.
Publication type:
Article
Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective.
Published in:
Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 1, p. 88, doi. 10.1002/cpt.1013
By:
- Shebley, Mohamad;
- Emami Riedmaier, Arian;
- Beneton, Maud;
- Bouzom, Francois;
- Chen, Jun;
- Djebli, Nassim;
- Chen, Yuan;
- Yoshida, Kenta;
- Cleary, Yumi;
- Collins, Christiane;
- Dickinson, Gemma L.;
- Einolf, Heidi J.;
- Huth, Felix;
- Khalil, Feras;
- Sandhu, Punam;
- Lin, Jing;
- Odinecs, Aleksandrs;
- Patel, Chirag;
- Schuck, Edgar;
- Wu, Shu‐Pei
Publication type:
Article

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