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- Title
Gut Colonization of Healthy Children and Their Mothers With Pathogenic Ciprofloxacin-Resistant Escherichia coli.
- Authors
Gurnee, Emily A.; Ndao, I. Malick; Johnson, James R.; Johnston, Brian D.; Gonzalez, Mark D.; Burnham, Carey-Ann D.; Hall-Moore, Carla M.; McGhee, Jessica E.; Mellmann, Alexander; Warner, Barbara B.; Tarr, Phillip I.
- Abstract
<bold>Background: </bold>The reservoir of pathogenic ciprofloxacin-resistant Escherichia coli remains unknown.<bold>Methods: </bold>We conducted a prospective cohort study of 80 healthy twins and their mothers to determine the frequency of excretion of ciprofloxacin-resistant, potentially pathogenic E. coli. Stool specimens were cultured selectively for ciprofloxacin-resistant gram-negative bacteria. Isolates were categorized on the basis of additional resistance and virulence profiles. We also prospectively collected clinical metadata.<bold>Results: </bold>Fifteen children (19%) and 8 mothers (20%) excreted ciprofloxacin-resistant E. coli at least once. Overall, 33% of 40 families had at least 1 member whose stool specimen yielded ciprofloxacin-resistant E. coli on culture. Fifty-seven submitted stool specimens (2.8%) contained such organisms; clones ST131-H30 and ST405 accounted for 52 and 5 of the positive specimens, respectively. Length of hospital stay after birth (P = .002) and maternal colonization (P = .0001) were associated with subsequent childhood carriage of ciprofloxacin-resistant E. coli; antibiotic use, acid suppression, sex, mode of delivery, and maternal perinatal antibiotic use were not. Ciprofloxacin-resistant E. coli were usually resistant to additional antibiotic classes, and all had virulence genotypes typical of extraintestinal pathogenic E. coli.<bold>Conclusions: </bold>Healthy children and their mothers commonly harbor ciprofloxacin-resistant E. coli with pathogenic potential.
- Subjects
BACTERIAL colonies; CIPROFLOXACIN; DRUG resistance in bacteria; GUT microbiome; GRAM-negative bacteria; MOTHER-child relationship; MICROBIAL virulence; FECAL analysis; ESCHERICHIA coli; ANTIBIOTICS; CARRIER state (Communicable diseases); DRUG resistance in microorganisms; ESCHERICHIA coli diseases; FECES; GENETIC techniques; LONGITUDINAL method; RESEARCH funding; DISEASE prevalence; HUMAN research subjects; GENOTYPES; PHARMACODYNAMICS
- Publication
Journal of Infectious Diseases, 2015, Vol 212, Issue 12, p1862
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiv278