We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Periodontal Therapy Reduces Plasma Levels of Interleukin-6, C-Reactive Protein, and Fibrinogen in Patients With Severe Periodontitis and Refractory Arterial Hypertension.
- Authors
Vidal, Fábio; Figueredo, Carlos Marcelo S.; Cordovil, Ivan; Fischer, Ricardo G.
- Abstract
Background: Recent epidemiologic studies suggest that inflammation is the link between periodontal diseases and cardiovascular complications. This study aimed to evaluate the effects of non-surgical periodontal treatment on plasma levels of inflammatory markers (interleukin [IL]-6, C-reactive protein [CRP], and fibrinogen) in patients with severe periodontitis and refractory arterial hypertension. Methods: Twenty-two patients were examined and randomly divided into two groups. The test group was composed of 111 patients (mean age, 48.9 ± 3.9 years) who received periodontal treatment, whereas the control group had 11 patients (mean age, 49.7 ± 6.0 years) whose treatment was delayed for 3 months. Demographic and clinical periodontal data were collected, and blood tests were performed to measure the levels of IL-6, CRP, and fibrinogen at baseline and 3 months later. Results: The clinical results showed that the mean percentages of sites with bleeding on probing, probing depth (PD) 4 to 5 mm, PD ≥6 mm, clinical attachment loss (CAL) 4 to 5 mm, and CAL ≥6 mm were significantly reduced in the test group 3 months after periodontal treatment. There were no significant differences between the data at baseline and 3 months in the control group. Periodontal treatment significantly reduced the blood levels of fibrinogen, CRP, and IL-6 in the test group. Conclusion: Non-surgical periodontal therapy was effective in improving periodontal clinical data and in reducing the plasma levels of IL-6, CRP, and fibrinogen in hypertensive patients with severe periodontitis.
- Subjects
PERIODONTAL disease treatment; PERIODONTITIS; HYPERTENSION; INTERLEUKIN-6; C-reactive protein; FIBRINOGEN; INFLAMMATION; CARDIOVASCULAR diseases; PATIENTS
- Publication
Journal of Periodontology, 2009, Vol 80, Issue 5, p786
- ISSN
0022-3492
- Publication type
Article
- DOI
10.1902/jop.2009.080471