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- Title
Regucalcin (RGN/SMP30) alters agonist- and thapsigargin-induced cytosolic [Ca<sup>2+</sup>] transients in cells by increasing SERCA Ca<sup>2+</sup>ATPase levels
- Authors
Lai, Pei; Yip, Nga Chi; Michelangeli, Francesco
- Abstract
Abstract: Regucalcin (RGN), also reported as senescence marker protein-30 (SMP30), plays a role in Ca2+ homeostasis by modulating a number of Ca2+-dependent proteins. RGN also plays a cyto-protective role and its decrease is linked to age-related diseases and cell death. This study shows that RGN reduces agonist (histamine)-induced Ca2+ transients in RGN+ transfected COS-7 cells (RGN+) and also increases their Ca2+ storage capacity. These observations are explained by RGN+ cells having increased mRNA and protein expression levels of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). Therefore down-regulation of RGN expression may contribute to characteristics of age-dependent Ca2+ homeostasis dis-regulation, by decreasing SERCA levels.
- Subjects
CALCIUM-binding proteins; ENZYME inhibitors; CALCIUM; ADENOSINE triphosphatase; ENDOPLASMIC reticulum; AGING; POLYMERASE chain reaction; CYTOSOL
- Publication
FEBS Letters, 2011, Vol 585, Issue 14, p2291
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2011.05.058