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- Title
Nuclear receptors: Decoding metabolic disease
- Authors
Sonoda, Junichiro; Pei, Liming; Evans, Ronald M.
- Abstract
Abstract: Nuclear receptors (NR) are a superfamily of ligand-activated transcription factors that regulate development, reproduction, and metabolism of lipids, drugs and energy. The importance of this family of proteins in metabolic disease is exemplified by NR ligands used in the clinic or under exploratory development for the treatment of diabetes mellitus, dyslipidemia, hypercholesterolemia, or other metabolic abnormalities. Genetic studies in humans and rodents support the notion that NRs control a wide variety of metabolic processes by regulating the expression of genes encoding key enzymes, transporters and other proteins involved in metabolic homeostasis. Current knowledge of complex NR metabolic networks is summarized here.
- Subjects
METABOLIC disorders; NUCLEAR receptors (Biochemistry); TRANSCRIPTION factors; DRUG resistance
- Publication
FEBS Letters, 2008, Vol 582, Issue 1, p2
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.11.016