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- Title
Clinical implications of compromised <sup>82</sup>Rb PET data acquisition.
- Authors
Van Tosh, Andrew; Cao, J. Jane; Votaw, John R.; Cooke, C. David; Palestro, Christopher J.; Nichols, Kenneth J.
- Abstract
Background: We wished to document the prevalence and quantitative effects of compromised 82Rb PET data acquisitions on myocardial flow reserve (MFR). Methods and Results: Data were analyzed retrospectively for 246 rest and regadenoson-stress studies of 123 patients evaluated for known or suspected CAD. An automated injector delivered pre-determined activities of 82Rb. Automated quality assurance algorithms identified technical problems for 7% (9/123) of patients. Stress data exhibited 2 instances of scanner saturation, 1 blood peak detection, 1 blood peak width, 1 gradual patient motion, and 2 abrupt patient motion problems. Rest data showed 1 instance of blood peak width and 2 abrupt patient motion problems. MFR was lower for patients with technical problems flagged by the quality assurance algorithms than those without technical problems (1.5 ± 0.5 versus 2.1 ± 0.7, P = 0.01), even though rest and stress ejection fraction, asynchrony and relative myocardial perfusion measures were similar for these two groups (P > 0.05), suggesting that MFR accuracy was adversely affected by technical errors. Conclusion: It is important to verify integrity of 82Rb data to ensure MFR computation quality.
- Subjects
ACQUISITION of data; QUALITY assurance; VENTRICULAR ejection fraction; DATA integrity; BLOOD flow
- Publication
Journal of Nuclear Cardiology, 2022, Vol 29, Issue 5, p2583
- ISSN
1071-3581
- Publication type
Article
- DOI
10.1007/s12350-021-02774-9