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- Title
p38 MAPK is involved in CB<sub>2</sub> receptor-induced apoptosis of human leukaemia cells
- Authors
Herrera, Blanca; Carracedo, Arkaitz; Diez-Zaera, María; Guzmán, Manuel; Velasco, Guillermo
- Abstract
Abstract: Cannabinoids have been shown to inhibit the growth of a broad spectrum of tumour cells. However, the molecular mechanisms involved in that effect have not been completely elucidated. Here, we investigated the possible involvement of mitogen-activated protein kinases (MAPKs) in CB2 receptor-induced apoptosis of human leukaemia cells. Results show that stimulation of the CB2 receptor leads to p38 MAPK activation and that inhibition of this kinase attenuates CB2 receptor-induced caspase activation and apoptosis. These findings support a role for p38 MAPK in CB2 receptor-induced apoptosis of human leukaemia cells.
- Subjects
APOPTOSIS; CANNABINOIDS; PROTEIN kinases; ORGANIC compounds
- Publication
FEBS Letters, 2005, Vol 579, Issue 22, p5084
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.08.021