We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Loss of filament-forming ability of myosin by non-enzymatic glycosylation and its molecular mechanism
- Authors
Katayama, Shigeru; Haga, Yoshiaki; Saeki, Hiroki
- Abstract
Carp and scallop myosin and their subfragments (S-1 and rod) were reacted with glucose to investigate the effect of non-enzymatic glycosylation on the functionality of myosin. The filament-forming ability of the myosin rod diminished with the progress of non-enzymatic glycosylation and myosin became soluble in 0.1 M NaCl. The inhibition of the self-assembly of myosin molecules occurred chemically as a result of the increase in negative charge repulsion among myosin molecules and, further, physically as a result of the introduction of the glycosyl units into the surface of the rod region.
- Subjects
MYOSIN; GLYCOSYLATION; MUSCLE proteins; SUGARS
- Publication
FEBS Letters, 2004, Vol 575, Issue 1-3, p9
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2004.08.029