We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Gender differences in outcome in patients with diabetes mellitus.
- Authors
Romero-Farina, Guillermo; Aguadé-Bruix, Santiago; Cuellar-Calabria, Hug; Pizzi, María Nazarena; Roque, Albert; Candell-Riera, Jaume
- Abstract
Background: Diabetes mellitus is an independent risk factor in the development of coronary artery disease (CAD), myocardial infarction (MI), and cardiac death (CD). The major adverse cardiac events (MACEs) between men and women in diabetic patients stratified by CAD (previous MI and/or coronary revascularization, CR) were analyzed. Methods and Results: A cohort of 1327 consecutive diabetic patients (age 66.5 ± 9 years) underwent gated SPECT (single-photon emission computed tomography). During a mean follow-up of 4.7 ± 2.2 years post gated SPECT, MACEs (non-fatal MI, CD, and late CR) were evaluated according to gender stratified by CAD. Among diabetic patients without known CAD (N = 731), men had more MACEs (sHR 1.9;95%CI 1.2-3.2) than women. Among diabetic patients with known CAD (N = 596), there was no difference in MACEs in diabetic men and women (sHR 1.15;95%CI 0.73-1.8). Diabetic women with known CAD (n = 143) were the group with the highest risk (sHR 1.7; P =.041) for MACEs (4.5% MACEs/year, [95%CI 3.1%-6.4%]), compared to the remaining diabetic patients (N = 1184) (3% MACEs/year, [95%CI 2.6%-3.5%]). Conclusions: The prognosis of diabetic patients for MACEs is different in men and women stratified by CAD. The worst prognosis for MACEs occurs in women with known CAD.
- Subjects
SINGLE-photon emission computed tomography; MAJOR adverse cardiovascular events; PEOPLE with diabetes; DIABETES; MYOCARDIAL infarction; CORONARY artery disease; TYPE 2 diabetes
- Publication
Journal of Nuclear Cardiology, 2022, Vol 29, Issue 1, p72
- ISSN
1071-3581
- Publication type
Article
- DOI
10.1007/s12350-020-02195-0