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- Title
Hair pigment distribution changes after haematopoietic stem cell transplantation in Griscelli syndrome type 2.
- Authors
Yamazaki‐Nakashimada, M.A.; Roldán‐Marín, R.; Toussaint‐Caire, S.; Olaya‐Vargas, A.; Ramírez‐Uribe, N.; Rivas‐Larrauri, F.; Durán‐McKinster, C.; Alcántara‐Ortigoza, M.A.; González‐del Angel, A.; Orozco‐Covarrubias, L.; Scheffler‐Mendoza, S.; Saez‐de‐Ocariz, M.
- Abstract
Griscelli syndrome type 2 (GS2) features silvery-grey hair, bronzed skin and immunodeficiency.1 The only curative treatment for GS2 is haematopoietic stem cell transplantation (HSCT) which corrects the immune and haematologic defects with persistence of oculocutaneous abnormalities.2 We report three female patients with GS2 and successful HSCT who developed clinically evident decreased silvery-grey hair colour on the scalp, eyebrows and eyelashes, between 18 months and two years after transplantation. Hair shafts obtained both pre- and post-HSCT were analysed under light and polarized microscopy, and hair shafts post-HSCT were studied I in vivo i under trichoscopy and reflectance confocal microscopy.
- Subjects
STEM cell transplantation; HAIR
- Publication
Journal of the European Academy of Dermatology & Venereology, 2021, Vol 35, Issue 1, pe53
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/jdv.16795