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- Title
Self-sampling to improve cervical cancer screening coverage in Switzerland: a randomised controlled trial.
- Authors
Viviano, Manuela; Catarino, Rosa; Jeannot, Emilien; Boulvain, Michel; Malinverno, Manuela Undurraga; Vassilakos, Pierre; Petignat, Patrick
- Abstract
<bold>Background: </bold>The aim of this study is to evaluate whether self-sampling can increase screening attendance of women who do not attend regular screening in Switzerland.<bold>Methods: </bold>Participants were proactively recruited in Geneva between September 2011 and November 2015. Women (25-69 years) who had not undergone CC screening in the last 3 years were considered eligible. Through a 1 : 1 ratio randomisation, enrolled participants were invited to either undergo liquid-based cytology, which was performed by a health-care provider (control group, CG) or to take a self-sample for HPV-testing, which was mailed to their home (intervention group, IG).<bold>Results: </bold>A total of 331 and 336 women were randomised in the CG and in the IG, respectively. Overall, 7.3% (95% CI: 4.9-10.6) women in the CG and 5.7% (95% CI: 3.6-8.7) women in the IG did not undergo the initial screening (P=0.400). There were 1.95% (95% CI: 0.8-4.3) women in the CG and 5.05% (95% CI: 3.1-8.1) women in the IG with a positive screen who did not attend triage and colposcopy (P=0.036).<bold>Conclusions: </bold>The participation in CC screening in women offered self-sampling was not higher than among those offered specimen collection by a clinician. Compliance with further follow-up for women with a positive HPV test on the self-sample requires further attention.
- Subjects
SWITZERLAND; PAPILLOMAVIRUS disease diagnosis; CERVICAL intraepithelial neoplasia; COLLECTION &; preservation of biological specimens; CERVICAL cancer; COLPOSCOPY; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; PAPILLOMAVIRUS diseases; RESEARCH; HEALTH self-care; SQUAMOUS cell carcinoma; MEDICAL triage; CERVIX uteri tumors; EVALUATION research; RANDOMIZED controlled trials; PATIENTS' attitudes; EARLY detection of cancer; DIAGNOSIS
- Publication
British Journal of Cancer, 2017, Vol 116, Issue 11, p1382
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/bjc.2017.111