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- Title
Exercise Training in Children with Obesity.
- Authors
Chu, L.; Morrison, K. M.; Riddell, M. C.; Raha, S.; Timmons, B. W.
- Abstract
Background: The capacity to match carbohydrate (CHO) utilization with CHO availability (i.e., metabolic flexibility) is important, especially for children at risk for developing type 2 diabetes. In adults, impaired metabolic flexibility is associated with insulin resistance, and evidence suggests that 7-days of exercise training can improve insulin resistance. The responsiveness of metabolic flexibility to exercise training in children is unknown. We hypothesized that 7-days of exercise training would improve metabolic flexibility and insulin resistance in children with obesity. Methods: Participants visited the McMaster Children's Hospital on 2 separate days before and after 7 consecutive days of exercise training. At visit 1, fasting blood work was completed, and anthropometry, body composition and aerobic fitness (VO2max) were assessed. At visit 2, a 13C-enriched CHO drink was ingested 30 min before exercise (3 x 20 min bouts with 5 min breaks) at 45% VO2max. Breath measurements were collected to calculate exogenous CHO oxidation and determine the oxidative efficiency of exogenous CHO (metabolic flexibility). Stationary bikes were transported to the participant's homes for supervised sessions, which consisted of alternating between continuous exercise (3 x 15 min at 80% HRmax) and high intensity interval exercise (6 sets of 4 x 15 sec sprints). Visits 1 and 2 were then repeated at least 48 hours after the exercise training. Results: Preliminary results showed 7 out of the 9 participants improved their metabolic flexibility after exercise training (20.8 ± 1.9% to 23.4 ± 2.7%), but mean differences were not significant in the entire group (20.7 ± 1.9%, 21.8 ± 4.2%; p=0.33). As expected, no changes in percent body fat (44.6 ± 5.2%, 44.6 ± 5.4%;; p=1.00) or VO2max (22.5 ± 5.1 ml/kg/min, 22.3 ± 3.7 ml/kg/min;; p=0.83) were found after training. Discussion: These findings suggest that 7-days of exercise training improved metabolic flexibility in some children with obesity, but not all. Future analysis will be conducted in more participants to confirm. HOMA-IR will also be measured to determine if exercise training improved insulin resistance. This research was funded by the Canadian Institutes of Health Research.
- Subjects
BODY composition; BREATH tests; CYCLING; ENERGY metabolism in children; EXERCISE; CARBOHYDRATE content of food; INSULIN resistance; LONGITUDINAL method; CHILDHOOD obesity; HEALTH outcome assessment; PROBABILITY theory; RESEARCH funding; OXYGEN consumption
- Publication
Pediatric Exercise Science, 2016, Vol 28, p21
- ISSN
0899-8493
- Publication type
Article