We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Biologics Beyond Boundaries: Innovative Use of Biologics in Dermatology.
- Authors
De, Abhishek; Chowdhury, Barnali; Khemka, Monika; Sarda, Aarti; Das, Sudip
- Abstract
Several biologic agents have been approved for use in dermatology and other disciplines of medicine. However, based on the mechanism of action and a track record of the response, these agents are being increasingly used for off-label purposes to garner control of more remote and difficult disease processes. Herein, we present three difficult to treat patients where innovative uses of biologics beyond their approved indications have yielded good responses. Our first patient was a case of bullous pemphigoid, who showed excellent response to omalizumab. The second case was a patient of lepromatous leprosy with tenosynovitis and erythema nodosum leprosum, who was treated effectively with infliximab. Our third case was a treatment-resistant pyoderma gangrenosum, where infliximab showed a very good response. In the present study, we report the cases to highlight the usefulness of biologics that can expand much beyond the routine FDA approved indications.
- Subjects
DRUG therapy for Hansen's disease; HANSEN'S disease diagnosis; BIOTHERAPY; THERAPEUTIC use of monoclonal antibodies; STEROID drugs; TENOSYNOVITIS; DRUG efficacy; LEPROSTATIC agents; ERYTHEMA nodosum; BIOPSY; FLUOROIMMUNOASSAY; BULLOUS pemphigoid; INFLIXIMAB; DERMATOLOGIC agents; PYODERMA gangrenosum; NEEDLE biopsy
- Publication
Indian Journal of Dermatology, 2021, Vol 66, Issue 3, p314
- ISSN
0019-5154
- Publication type
Article
- DOI
10.4103/ijd.IJD_128_20