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- Title
Celebrating 75 years of Anaesthesia: our past, present and future. The science of neuromusclar blockade, 75 years on.
- Authors
Charlesworth, M.; Klein, A. A.
- Abstract
Celebrating 75 years of Anaesthesia: our past, present and future. At the time, the balance between achieving optimal neuromuscular blockade to facilitate surgery and the need to avoid excessive depth of anaesthesia was a cause of much concern, and the use of intocostrin (curare) was postulated as a new and exciting solution. Depth of anaesthesia Mallinson reminds us of Guedel's classification of clinically assessing the depth of anaesthesia. Mallinson was correct that neuromuscular blocking drugs made surgery more practicable and effective, and arguably revolutionised the practice of anaesthesia; however, he could not have foreseen their association with two of the most feared peri-operative complications for patients and anaesthetists alike: accidental awareness during general anaesthesia; and residual neuromuscular blockade following recovery from anaesthesia.
- Subjects
YEAR; ANESTHESIA; NEUROMUSCULAR blockade; INTRAOPERATIVE awareness; WORLD War II; NEUROMUSCULAR blocking agents
- Publication
Anaesthesia, 2021, Vol 76, Issue 1, p128
- ISSN
0003-2409
- Publication type
journal article
- DOI
10.1111/anae.15287