We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Primary central nervous system lymphoma in a child with acute B-cell lymphoblastic leukaemia: consecutive Epstein-Barr virus-related malignancies.
- Authors
Buckingham, Steven C.; Benaim, Ely; Sandlund, John T.; Gan, Yan-Jun; Freiden, Pamela J.; Behm, Fred G.; Ribeiro, Raul C.; Sixbey, John W.; Slobod, Karen S.
- Abstract
Primary central nervous system lymphoma (PCNSL), observed among immunocompromised AIDS patients, has not been reported during chemotherapy for acute lymphoblastic leukaemia (ALL). We report a case of PCNSL occurring in a child receiving intensive multiagent chemotherapy for B-cell ALL. In situ hybridization studies demonstrated Epstein-Barr virus genome in both tumours, suggesting a possible link between the two diseases. The clinical response of the PCNSL to conservative therapy highlights the importance of accurately diagnosing such EBV-related disorders, especially in patients where immune compromise can be reversed.
- Subjects
LYMPHOMAS; LYMPHOBLASTIC leukemia in children
- Publication
British Journal of Haematology, 1998, Vol 101, Issue 2, p345
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.1998.00709.x