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- Title
Fibroblast activation protein α identifies mesenchymal stromal cells from human bone marrow.
- Authors
Bae, Sohyun; Park, Chae Woon; Son, Hye Kyung; Ju, Hye Kyung; Paik, Donggi; Jeon, Choon-Ju; Koh, Gou Young; Kim, Jaeseob; Kim, Hoeon
- Abstract
Mesenchymal stromal cells (MSCs) have gained widespread popularity in cell therapy, but their development into clinical products has been impeded by the scarcity of cell-specific markers. We previously explored transcriptome and membrane proteome of MSCs, from which fibroblast activation protein α (FAP) was recognized as a prime surface marker candidate. The present study showed that FAP was constitutively expressed on MSCs, but not on other cells. FAP immunoselection yielded homogeneous MSCs from cryopreserved bone marrow (BM). These results suggest that FAP serves as a surface protein marker that can singly define MSCs from BM and possibly from other sources.
- Subjects
CONNECTIVE tissue cells; STEM cells; HEMATOLOGY; CELL surface antigens; BONE marrow -- Preservation
- Publication
British Journal of Haematology, 2008, Vol 142, Issue 5, p827
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2008.07241.x