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- Title
Cystatin F a potential diagnostic biomarker in acute promyelocytic leukemia.
- Authors
Palani, Hamenth Kumar; Ganesan, Saravanan; Balasundaram, Nithya; Venkatraman, Arvind; Kulkarni, Uday; Korula, Anu; Nair, Sukesh C; Mani, Thenmozhi; Balasubramanian, Poonkuzhali; Abraham, Aby; Puttamallesh, Vinuth N; Gowda, Harsha; Mathews, Vikram
- Abstract
A letter published in the Annals of Hematology discusses the need for a diagnostic test with a short turnaround time for acute promyelocytic leukemia (APL). The authors conducted a proteomic analysis to identify a unique protein biomarker in APL. They found that cystatin F, a secretory protein found in extracellular space and body fluids, was significantly overexpressed in APL cells compared to other types of leukemia and healthy control cells. The authors suggest that cystatin F could be a potential biomarker for the rapid diagnosis of APL and the initiation of appropriate therapies.
- Subjects
ACUTE promyelocytic leukemia; ARSENIC trioxide; BIOMARKERS
- Publication
Annals of Hematology, 2024, Vol 103, Issue 6, p2181
- ISSN
0939-5555
- Publication type
Article
- DOI
10.1007/s00277-024-05673-4